Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 787671..788469 Replicon chromosome
Accession NZ_CP085183
Organism Escherichia coli strain EC7518

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag LIN51_RS03785 Protein ID WP_000854735.1
Coordinates 787671..788048 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag LIN51_RS03790 Protein ID WP_032153712.1
Coordinates 788095..788469 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN51_RS03755 (783639) 783639..784901 - 1263 WP_001218875.1 integrase arm-type DNA-binding domain-containing protein -
LIN51_RS03760 (785365) 785365..785691 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
LIN51_RS03765 (785688) 785688..785951 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
LIN51_RS03770 (786023) 786023..786889 - 867 WP_032153714.1 DUF4942 domain-containing protein -
LIN51_RS03775 (786974) 786974..787171 - 198 WP_000839265.1 DUF957 domain-containing protein -
LIN51_RS03780 (787183) 787183..787674 - 492 WP_023155722.1 DUF5983 family protein -
LIN51_RS03785 (787671) 787671..788048 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
LIN51_RS03790 (788095) 788095..788469 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LIN51_RS03795 (788549) 788549..788770 - 222 WP_000692345.1 DUF987 domain-containing protein -
LIN51_RS03800 (788839) 788839..789315 - 477 WP_001186715.1 RadC family protein -
LIN51_RS03805 (789331) 789331..789816 - 486 WP_032153711.1 antirestriction protein -
LIN51_RS03810 (789908) 789908..790726 - 819 WP_001234693.1 DUF932 domain-containing protein -
LIN51_RS03815 (790817) 790817..791026 - 210 WP_023155727.1 DUF905 family protein -
LIN51_RS03820 (791056) 791056..791733 - 678 WP_023155728.1 hypothetical protein -
LIN51_RS03825 (791852) 791852..792736 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T220533 WP_000854735.1 NZ_CP085183:c788048-787671 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T220533 NZ_CP117166:3151022-3151591 [Proteus mirabilis]
ATGACAAACTATACTGTTTTGCTTGATGCCTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTCGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGGCAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAATACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGAATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCCCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT220533 WP_032153712.1 NZ_CP085183:c788469-788095 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT220533 NZ_CP117166:3150570-3151022 [Proteus mirabilis]
ATGAATACGATAAGTGAGAGACTTAGTGCTGAAGATATTGCATTAGCAAAATTAAGTAGCCAAGAGCTATCCGCTGTTAT
GGATATTAATGGCAAAACGCAGAAGCTATCCATTATAGATAAGACGGGTAATAATCATATTGTACAAATACCAAATAGTG
CATTACGCCTAATGATTGAAATTCTTACTCAACTAGGGCAAGGGAATACTGTTAGTATCACACCAATCCATGCTGAGCTA
ACGACACAGGAAGCGGCTGATATACTCAATATGTCCCGTCCTACATTTGTAAAATTATTAGATACACGAGCGATACCCTA
CTCTAGAAAAGGAAATCGTAGGAAAGTTGCTTATGCTGATATTGTTGCTTATAAAAATGAATTGGAGCAAAAACGACTTG
ATGCCCTTGCTGAATTATCGCAATTAGATCAAGAAATGGATATGGGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References