Detailed information of TA system TA022053

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3618488..3619148
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ENT638_RS17135
• Protein ID: WP_015960305.1
• Coordinates: 3618488..3618901 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A3S5XU93
• Locus tag: ENT638_RS17140
• Protein ID: WP_015960306.1
• Coordinates: 3618882..3619148 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS17115	3614484..3616217	-	1734	WP_015960301.1	single-stranded-DNA-specific exonuclease RecJ	-
ENT638_RS17120	3616223..3616936	-	714	WP_015960302.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ENT638_RS17125	3616965..3617861	-	897	WP_015960303.1	site-specific tyrosine recombinase XerD	-
ENT638_RS17130	3617962..3618483	+	522	WP_015960304.1	flavodoxin FldB	-
ENT638_RS17135	3618488..3618901	-	414	WP_015960305.1	protein YgfX	Toxin
ENT638_RS17140	3618882..3619148	-	267	WP_015960306.1	FAD assembly factor SdhE	Antitoxin
ENT638_RS17145	3619416..3620396	+	981	WP_015960307.1	tRNA-modifying protein YgfZ	-
ENT638_RS17150	3620439..3621098	-	660	WP_041689508.1	hemolysin III family protein	-
ENT638_RS17155	3621262..3621573	-	312	WP_041689509.1	N(4)-acetylcytidine aminohydrolase	-
ENT638_RS17160	3621626..3622357	+	732	WP_015960310.1	MurR/RpiR family transcriptional regulator	-
ENT638_RS17165	3622473..3623906	+	1434	WP_015960311.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16205.05 Da
• Isoelectric Point: 11.1910

>T22053 WP_015960305.1 NC_009436:c3618901-3618488 [Enterobacter sp. 638]
VVLWQSDLRVSWRSQWMSLLLHGMVAAFVLLMPWPLSYTPLWMLLLSLVVFDSVRSQRRINSCQGEIKLLMDSRLRWQGK
EWEIVGTPWMLSFGMMFRLRNAQGGRSQHLWLSADSMDADEWRDLRRMVLQQPTPGR

Nucleotide

• Length: 414 bp

>T22053 NC_009436:c3618901-3618488 [Enterobacter sp. 638]
GTGGTCCTGTGGCAATCTGATCTGCGCGTTTCGTGGCGCTCACAGTGGATGTCTTTGTTACTCCACGGAATGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCACTTAGCTACACCCCGTTATGGATGCTGTTACTCTCGCTGGTCGTTTTCGATAGCG
TGCGCAGCCAGCGACGTATCAATTCCTGTCAGGGCGAAATTAAGCTGCTGATGGACTCGCGTCTACGCTGGCAAGGTAAA
GAGTGGGAAATCGTCGGTACGCCCTGGATGCTGAGTTTTGGCATGATGTTTCGCTTGCGTAACGCGCAAGGCGGACGAAG
CCAGCATTTATGGCTTTCGGCGGACAGTATGGATGCTGACGAGTGGCGAGATTTGCGTCGGATGGTTTTACAGCAACCGA
CGCCCGGTCGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10528.00 Da
• Isoelectric Point: 5.1340

>AT22053 WP_015960306.1 NC_009436:c3619148-3618882 [Enterobacter sp. 638]
MDISNKARIHWACRRGMRELDISVMPFFEYEYDSLSDDDKRLFIRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT22053 NC_009436:c3619148-3618882 [Enterobacter sp. 638]
ATGGACATTAGCAATAAGGCTCGTATTCACTGGGCGTGCCGTCGCGGCATGCGCGAACTTGATATTTCCGTCATGCCATT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGTCTATTTATTCGCCTTCTTGAAAGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3S5XU93