Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 245771..246311 | Replicon | plasmid pDSM109990_a |
| Accession | NZ_CP085145 | ||
| Organism | Sulfitobacter dubius strain DSM 109990 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | DSM109990_RS17345 | Protein ID | WP_243263336.1 |
| Coordinates | 246018..246311 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | DSM109990_RS17340 | Protein ID | WP_243263334.1 |
| Coordinates | 245771..246028 (+) | Length | 86 a.a. |
Genomic Context
Location: 244145..245140 (996 bp)
Type: Others
Protein ID: WP_243263332.1
Type: Others
Protein ID: WP_243263332.1
Location: 245771..246028 (258 bp)
Type: Antitoxin
Protein ID: WP_243263334.1
Type: Antitoxin
Protein ID: WP_243263334.1
Location: 246018..246311 (294 bp)
Type: Toxin
Protein ID: WP_243263336.1
Type: Toxin
Protein ID: WP_243263336.1
Location: 246796..247821 (1026 bp)
Type: Others
Protein ID: WP_243263311.1
Type: Others
Protein ID: WP_243263311.1
Location: 248204..249229 (1026 bp)
Type: Others
Protein ID: WP_243263311.1
Type: Others
Protein ID: WP_243263311.1
Location: 241365..242429 (1065 bp)
Type: Others
Protein ID: WP_243263330.1
Type: Others
Protein ID: WP_243263330.1
Location: 242426..243148 (723 bp)
Type: Others
Protein ID: WP_243263531.1
Type: Others
Protein ID: WP_243263531.1
Location: 243304..243966 (663 bp)
Type: Others
Protein ID: WP_243263532.1
Type: Others
Protein ID: WP_243263532.1
Location: 246336..246545 (210 bp)
Type: Others
Protein ID: WP_243263337.1
Type: Others
Protein ID: WP_243263337.1
Location: 249545..250303 (759 bp)
Type: Others
Protein ID: WP_243263339.1
Type: Others
Protein ID: WP_243263339.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DSM109990_RS17320 (DSM109990_03514) | 241365..242429 | - | 1065 | WP_243263330.1 | NAD(P)-dependent oxidoreductase | - |
| DSM109990_RS17325 (DSM109990_03515) | 242426..243148 | - | 723 | WP_243263531.1 | ABC transporter permease | - |
| DSM109990_RS17330 (DSM109990_03516) | 243304..243966 | - | 663 | WP_243263532.1 | TetR family transcriptional regulator | - |
| DSM109990_RS17335 (DSM109990_03517) | 244145..245140 | + | 996 | WP_243263332.1 | ABC transporter substrate-binding protein | - |
| DSM109990_RS17340 (DSM109990_03518) | 245771..246028 | + | 258 | WP_243263334.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| DSM109990_RS17345 (DSM109990_03519) | 246018..246311 | + | 294 | WP_243263336.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DSM109990_RS17350 (DSM109990_03520) | 246336..246545 | - | 210 | WP_243263337.1 | hypothetical protein | - |
| DSM109990_RS17355 (DSM109990_03522) | 246796..247821 | + | 1026 | WP_243263311.1 | IS110 family transposase | - |
| DSM109990_RS17360 (DSM109990_03523) | 248204..249229 | + | 1026 | WP_243263311.1 | IS110 family transposase | - |
| DSM109990_RS17365 (DSM109990_03524) | 249545..250303 | - | 759 | WP_243263339.1 | IS21-like element helper ATPase IstB | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..284454 | 284454 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11321.83 Da Isoelectric Point: 5.0965
>T220524 WP_243263336.1 NZ_CP085145:246018-246311 [Sulfitobacter dubius]
MQDKPYALSPLAEIDLEEIWFYTFQKWSLAQADSYHRDLIATFEGLVSGTKRGREVDVRPDYLKCPVGSHMIYFRDSGDQ
MEVIRVLHQRQDATLNL
MQDKPYALSPLAEIDLEEIWFYTFQKWSLAQADSYHRDLIATFEGLVSGTKRGREVDVRPDYLKCPVGSHMIYFRDSGDQ
MEVIRVLHQRQDATLNL
Download Length: 294 bp
>T220524 NZ_CP117054:c793397-793095 [Vibrio harveyi]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACGAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAGCATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACGAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAGCATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9222.26 Da Isoelectric Point: 7.4705
>AT220524 WP_243263334.1 NZ_CP085145:245771-246028 [Sulfitobacter dubius]
MPRNTSVTLGTHFSDFIGEQVQTGRYGSASDVVRAGLRLLEEHETKVRALQDALIAGEQSGTPRSFDSDAFLSRMHAKHA
AKHAG
MPRNTSVTLGTHFSDFIGEQVQTGRYGSASDVVRAGLRLLEEHETKVRALQDALIAGEQSGTPRSFDSDAFLSRMHAKHA
AKHAG
Download Length: 258 bp
>AT220524 NZ_CP117054:c793642-793385 [Vibrio harveyi]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTTGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTTGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA