Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 70358..70928 Replicon plasmid pDSM109990_a
Accession NZ_CP085145
Organism Sulfitobacter dubius strain DSM 109990

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DSM109990_RS16590 Protein ID WP_243263446.1
Coordinates 70358..70684 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DSM109990_RS16595 Protein ID WP_243263447.1
Coordinates 70686..70928 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM109990_RS16570 (DSM109990_03358) 68042..68731 + 690 WP_243263442.1 phosphate regulon transcriptional regulator PhoB -
DSM109990_RS16575 (DSM109990_03359) 68868..69602 + 735 WP_243263443.1 IS30 family transposase -
DSM109990_RS16580 (DSM109990_03360) 69716..69970 + 255 WP_243263444.1 type II toxin-antitoxin system HicA family toxin -
DSM109990_RS16585 (DSM109990_03361) 69967..70314 + 348 WP_243263445.1 type II toxin-antitoxin system HicB family antitoxin -
DSM109990_RS16590 (DSM109990_03362) 70358..70684 - 327 WP_243263446.1 endoribonuclease MazF Toxin
DSM109990_RS16595 (DSM109990_03363) 70686..70928 - 243 WP_243263447.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DSM109990_RS16600 (DSM109990_03364) 71569..72918 + 1350 WP_243263448.1 Fic family protein -
DSM109990_RS16605 (DSM109990_03365) 73140..73391 + 252 WP_243263449.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
DSM109990_RS16610 (DSM109990_03366) 73388..73654 + 267 WP_243263450.1 Txe/YoeB family addiction module toxin -
DSM109990_RS16615 (DSM109990_03368) 73776..75098 - 1323 WP_243263451.1 glutamine synthetase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..284454 284454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-100)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11815.93 Da        Isoelectric Point: 10.0738

>T220521 WP_243263446.1 NZ_CP085145:c70684-70358 [Sulfitobacter dubius]
MAYIPEAGDIVWLQFNPQAGHEQVGHRPALVLSPAKYNKIGLMLCCPMTTKVKGYPFEVVIEGSPISAALADQVKSLDWK
VRRAKRKGQVTISELAEVRAKSVALIKG

Download         Length: 327 bp

>T220521 NZ_CP117053:c4507826-4507653 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8730.87 Da        Isoelectric Point: 4.2404

>AT220521 WP_243263447.1 NZ_CP085145:c70928-70686 [Sulfitobacter dubius]
MRVIVKKWGNSASVRIPAAIMQAAKLSLDTPVDVREENGRIIIEPDQSPEFLLDDLLNGITSDNAHASIETGEPLGQETF

Download         Length: 243 bp

>AT220521 NZ_CP117053:c4508150-4507854 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References