Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 70358..70928 | Replicon | plasmid pDSM109990_a |
| Accession | NZ_CP085145 | ||
| Organism | Sulfitobacter dubius strain DSM 109990 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | DSM109990_RS16590 | Protein ID | WP_243263446.1 |
| Coordinates | 70358..70684 (-) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | DSM109990_RS16595 | Protein ID | WP_243263447.1 |
| Coordinates | 70686..70928 (-) | Length | 81 a.a. |
Genomic Context
Location: 68042..68731 (690 bp)
Type: Others
Protein ID: WP_243263442.1
Type: Others
Protein ID: WP_243263442.1
Location: 68868..69602 (735 bp)
Type: Others
Protein ID: WP_243263443.1
Type: Others
Protein ID: WP_243263443.1
Location: 69716..69970 (255 bp)
Type: Others
Protein ID: WP_243263444.1
Type: Others
Protein ID: WP_243263444.1
Location: 69967..70314 (348 bp)
Type: Others
Protein ID: WP_243263445.1
Type: Others
Protein ID: WP_243263445.1
Location: 71569..72918 (1350 bp)
Type: Others
Protein ID: WP_243263448.1
Type: Others
Protein ID: WP_243263448.1
Location: 73140..73391 (252 bp)
Type: Others
Protein ID: WP_243263449.1
Type: Others
Protein ID: WP_243263449.1
Location: 73388..73654 (267 bp)
Type: Others
Protein ID: WP_243263450.1
Type: Others
Protein ID: WP_243263450.1
Location: 70358..70684 (327 bp)
Type: Toxin
Protein ID: WP_243263446.1
Type: Toxin
Protein ID: WP_243263446.1
Location: 70686..70928 (243 bp)
Type: Antitoxin
Protein ID: WP_243263447.1
Type: Antitoxin
Protein ID: WP_243263447.1
Location: 73776..75098 (1323 bp)
Type: Others
Protein ID: WP_243263451.1
Type: Others
Protein ID: WP_243263451.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DSM109990_RS16570 (DSM109990_03358) | 68042..68731 | + | 690 | WP_243263442.1 | phosphate regulon transcriptional regulator PhoB | - |
| DSM109990_RS16575 (DSM109990_03359) | 68868..69602 | + | 735 | WP_243263443.1 | IS30 family transposase | - |
| DSM109990_RS16580 (DSM109990_03360) | 69716..69970 | + | 255 | WP_243263444.1 | type II toxin-antitoxin system HicA family toxin | - |
| DSM109990_RS16585 (DSM109990_03361) | 69967..70314 | + | 348 | WP_243263445.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| DSM109990_RS16590 (DSM109990_03362) | 70358..70684 | - | 327 | WP_243263446.1 | endoribonuclease MazF | Toxin |
| DSM109990_RS16595 (DSM109990_03363) | 70686..70928 | - | 243 | WP_243263447.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| DSM109990_RS16600 (DSM109990_03364) | 71569..72918 | + | 1350 | WP_243263448.1 | Fic family protein | - |
| DSM109990_RS16605 (DSM109990_03365) | 73140..73391 | + | 252 | WP_243263449.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| DSM109990_RS16610 (DSM109990_03366) | 73388..73654 | + | 267 | WP_243263450.1 | Txe/YoeB family addiction module toxin | - |
| DSM109990_RS16615 (DSM109990_03368) | 73776..75098 | - | 1323 | WP_243263451.1 | glutamine synthetase family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..284454 | 284454 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 11815.93 Da Isoelectric Point: 10.0738
>T220521 WP_243263446.1 NZ_CP085145:c70684-70358 [Sulfitobacter dubius]
MAYIPEAGDIVWLQFNPQAGHEQVGHRPALVLSPAKYNKIGLMLCCPMTTKVKGYPFEVVIEGSPISAALADQVKSLDWK
VRRAKRKGQVTISELAEVRAKSVALIKG
MAYIPEAGDIVWLQFNPQAGHEQVGHRPALVLSPAKYNKIGLMLCCPMTTKVKGYPFEVVIEGSPISAALADQVKSLDWK
VRRAKRKGQVTISELAEVRAKSVALIKG
Download Length: 327 bp
>T220521 NZ_CP117053:c4507826-4507653 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8730.87 Da Isoelectric Point: 4.2404
>AT220521 WP_243263447.1 NZ_CP085145:c70928-70686 [Sulfitobacter dubius]
MRVIVKKWGNSASVRIPAAIMQAAKLSLDTPVDVREENGRIIIEPDQSPEFLLDDLLNGITSDNAHASIETGEPLGQETF
MRVIVKKWGNSASVRIPAAIMQAAKLSLDTPVDVREENGRIIIEPDQSPEFLLDDLLNGITSDNAHASIETGEPLGQETF
Download Length: 243 bp
>AT220521 NZ_CP117053:c4508150-4507854 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG