Detailed information of TA system TA022052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2811778..2812440
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ENT638_RS13485
• Protein ID: WP_041689691.1
• Coordinates: 2811778..2811960 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ENT638_RS13490
• Protein ID: WP_015959612.1
• Coordinates: 2812009..2812440 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS13450	2807143..2807529	-	387	WP_041689453.1	hypothetical protein	-
ENT638_RS13455	2807637..2807981	-	345	WP_015959606.1	hypothetical protein	-
ENT638_RS22305	2808385..2809074	-	690	WP_015959607.1	hypothetical protein	-
ENT638_RS13465	2809352..2809870	-	519	WP_015959608.1	Rha family transcriptional regulator	-
ENT638_RS23410	2810373..2810834	-	462	WP_015959609.1	lysis protein	-
ENT638_RS13475	2810831..2811367	-	537	WP_015959610.1	lysozyme	-
ENT638_RS13480	2811367..2811582	-	216	WP_015959611.1	class II holin family protein	-
ENT638_RS13485	2811778..2811960	+	183	WP_041689691.1	type II toxin-antitoxin system HicA family toxin	Toxin
ENT638_RS13490	2812009..2812440	+	432	WP_015959612.1	hypothetical protein	Antitoxin
ENT638_RS13495	2812698..2813096	-	399	WP_041689454.1	hypothetical protein	-
ENT638_RS13500	2813093..2813860	-	768	WP_015959613.1	hypothetical protein	-
ENT638_RS13505	2814222..2814800	-	579	WP_015959614.1	DUF1133 family protein	-
ENT638_RS13510	2814813..2815802	-	990	WP_015959615.1	DUF968 domain-containing protein	-
ENT638_RS22875	2815855..2815977	-	123	Protein_2682	DNA methyltransferase	-
ENT638_RS13515	2815974..2816894	-	921	WP_015959617.1	conserved phage C-terminal domain-containing protein	-
ENT638_RS22880	2816851..2817063	-	213	WP_071818752.1	DUF4222 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2787095..2825862	38767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6697.71 Da
• Isoelectric Point: 11.1572

>T22052 WP_041689691.1 NC_009436:2811778-2811960 [Enterobacter sp. 638]
VKYSEFLRWLKSQGVTIENARGGGSHRKATINGRKSIFPFHGSKEIPEGTRKSIIKDLGL

Nucleotide

• Length: 183 bp

>T22052 NC_009436:2811778-2811960 [Enterobacter sp. 638]
GTGAAATACAGCGAGTTCCTTCGCTGGTTAAAGTCCCAAGGAGTCACGATTGAAAATGCCAGAGGTGGTGGTAGCCACCG
GAAAGCAACAATCAACGGAAGGAAATCAATATTCCCCTTCCACGGCTCAAAGGAGATACCAGAGGGAACAAGAAAATCGA
TAATCAAGGATCTGGGGCTTTAG

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15874.97 Da
• Isoelectric Point: 4.5529

>AT22052 WP_015959612.1 NC_009436:2812009-2812440 [Enterobacter sp. 638]
MFRYSASVSFDNDAGQYEISFRDFENLHSVAFNEDDIELEARDALTAMVGELIDSRIPIPEPTTAQEGEIVIHLPVLTCL
KAALHNAMISTGTRKADLARKLNQKGPQIDRLLDVSHASKVETLEQALYLLGYEVSVSVVRVN

Nucleotide

• Length: 432 bp

>AT22052 NC_009436:2812009-2812440 [Enterobacter sp. 638]
ATGTTCAGATATTCCGCATCAGTTTCTTTTGACAACGATGCAGGTCAGTACGAGATTAGTTTTCGAGACTTCGAGAACCT
GCATTCTGTTGCATTCAACGAAGACGATATCGAGCTCGAAGCGCGAGACGCTTTAACAGCAATGGTTGGCGAACTGATTG
ATTCGCGCATACCAATACCAGAACCAACGACAGCTCAGGAGGGTGAGATTGTTATTCACCTTCCCGTTCTGACATGTCTC
AAAGCAGCTCTTCACAATGCGATGATCAGCACCGGTACGCGTAAGGCAGATTTGGCAAGAAAGCTTAATCAGAAAGGCCC
GCAAATTGACCGCTTGTTGGATGTTAGCCACGCATCAAAAGTCGAGACGCTGGAGCAAGCCTTATATCTCCTGGGATATG
AGGTTTCAGTGTCTGTTGTGAGAGTTAATTAA