Detailed information of TA system TA022052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2811778..2812440
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ENT638_RS13485
• Protein ID: WP_041689691.1
• Coordinates: 2811778..2811960 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ENT638_RS13490
• Protein ID: WP_015959612.1
• Coordinates: 2812009..2812440 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2787095..2825862	38767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6697.71 Da
• Isoelectric Point: 11.1572

>T22052 WP_041689691.1 NC_009436:2811778-2811960 [Enterobacter sp. 638]
VKYSEFLRWLKSQGVTIENARGGGSHRKATINGRKSIFPFHGSKEIPEGTRKSIIKDLGL

Nucleotide

• Length: 183 bp

>T22052 NC_009436:2811778-2811960 [Enterobacter sp. 638]
GTGAAATACAGCGAGTTCCTTCGCTGGTTAAAGTCCCAAGGAGTCACGATTGAAAATGCCAGAGGTGGTGGTAGCCACCG
GAAAGCAACAATCAACGGAAGGAAATCAATATTCCCCTTCCACGGCTCAAAGGAGATACCAGAGGGAACAAGAAAATCGA
TAATCAAGGATCTGGGGCTTTAG

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15874.97 Da
• Isoelectric Point: 4.5529

>AT22052 WP_015959612.1 NC_009436:2812009-2812440 [Enterobacter sp. 638]
MFRYSASVSFDNDAGQYEISFRDFENLHSVAFNEDDIELEARDALTAMVGELIDSRIPIPEPTTAQEGEIVIHLPVLTCL
KAALHNAMISTGTRKADLARKLNQKGPQIDRLLDVSHASKVETLEQALYLLGYEVSVSVVRVN

Nucleotide

• Length: 432 bp

>AT22052 NC_009436:2812009-2812440 [Enterobacter sp. 638]
ATGTTCAGATATTCCGCATCAGTTTCTTTTGACAACGATGCAGGTCAGTACGAGATTAGTTTTCGAGACTTCGAGAACCT
GCATTCTGTTGCATTCAACGAAGACGATATCGAGCTCGAAGCGCGAGACGCTTTAACAGCAATGGTTGGCGAACTGATTG
ATTCGCGCATACCAATACCAGAACCAACGACAGCTCAGGAGGGTGAGATTGTTATTCACCTTCCCGTTCTGACATGTCTC
AAAGCAGCTCTTCACAATGCGATGATCAGCACCGGTACGCGTAAGGCAGATTTGGCAAGAAAGCTTAATCAGAAAGGCCC
GCAAATTGACCGCTTGTTGGATGTTAGCCACGCATCAAAAGTCGAGACGCTGGAGCAAGCCTTATATCTCCTGGGATATG
AGGTTTCAGTGTCTGTTGTGAGAGTTAATTAA