Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3068787..3069334 Replicon chromosome
Accession NZ_CP085143
Organism Halomonas sp. NyZ770

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LG409_RS14215 Protein ID WP_227406958.1
Coordinates 3069035..3069334 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LG409_RS14210 Protein ID WP_144982072.1
Coordinates 3068787..3069035 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG409_RS14190 (LG409_14190) 3064891..3065625 + 735 WP_050980301.1 response regulator -
LG409_RS14195 (LG409_14195) 3065622..3066701 + 1080 WP_227406955.1 ATP-binding protein -
LG409_RS14200 (LG409_14200) 3066889..3067698 - 810 WP_227406956.1 sulfite exporter TauE/SafE family protein -
LG409_RS14205 (LG409_14205) 3067806..3068579 + 774 WP_227406957.1 helix-turn-helix transcriptional regulator -
LG409_RS14210 (LG409_14210) 3068787..3069035 + 249 WP_144982072.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LG409_RS14215 (LG409_14215) 3069035..3069334 + 300 WP_227406958.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LG409_RS14220 (LG409_14220) 3069279..3069566 - 288 WP_227406959.1 DUF808 family protein -
LG409_RS14225 (LG409_14225) 3069848..3071041 + 1194 WP_227406960.1 CmlA/FloR family chloramphenicol efflux MFS transporter -
LG409_RS14230 (LG409_14230) 3071076..3071657 - 582 WP_227406961.1 DedA family protein -
LG409_RS14235 (LG409_14235) 3072585..3073163 - 579 WP_227406962.1 hypothetical protein -
LG409_RS14240 (LG409_14240) 3073177..3073527 - 351 WP_227406963.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3058909..3089746 30837


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(3-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 12027.68 Da        Isoelectric Point: 6.9775

>T220517 WP_227406958.1 NZ_CP085143:3069035-3069334 [Halomonas sp. NyZ770]
MLTFRITPRARDDLKDIGRYTEWQWGKNQRDTYLRDFEKRFHWLAENPLPGRHRPDIKEGYFSYPQGQHVIFYLIGHECI
EIIGIPHKEMDIVSYFLTD

Download         Length: 300 bp

>T220517 NZ_CP117053:3875390-3875668 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.2690

>AT220517 WP_144982072.1 NZ_CP085143:3068787-3069035 [Halomonas sp. NyZ770]
MATTSLSLGEHWEAFIKNEVSSGRYGSASEVVRDALRAMEERKSKLEALRTHLAQGAEQASAGEFVDDFSMDALISDLDN
ES

Download         Length: 249 bp

>AT220517 NZ_CP117053:3875127-3875387 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References