Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2900271..2900773 Replicon chromosome
Accession NZ_CP085143
Organism Halomonas sp. NyZ770

Toxin (Protein)


Gene name relE Uniprot ID A0A857GIF8
Locus tag LG409_RS13470 Protein ID WP_016914643.1
Coordinates 2900519..2900773 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LG409_RS13465 Protein ID WP_227406879.1
Coordinates 2900271..2900522 (+) Length 84 a.a.

Genomic Context

LG409_RS13460LG409_RS13465LG409_RS13470LG409_RS13425LG409_RS13430LG409_RS13435LG409_RS13440LG409_RS13445LG409_RS13450LG409_RS13455LG409_RS13475LG409_RS13480LG409_RS13485LG409_RS13490LG409_RS13495LG409_RS13500
Location: 2899286..2900107 (822 bp)
Type: Others
Protein ID: WP_227406878.1
Location: 2900271..2900522 (252 bp)
Type: Antitoxin
Protein ID: WP_227406879.1
Location: 2900519..2900773 (255 bp)
Type: Toxin
Protein ID: WP_016914643.1
Location: 2895767..2896219 (453 bp)
Type: Others
Protein ID: WP_227406874.1
Location: 2896227..2896649 (423 bp)
Type: Others
Protein ID: WP_227406875.1
Location: 2896688..2897158 (471 bp)
Type: Others
Protein ID: WP_193460799.1
Location: 2897182..2897709 (528 bp)
Type: Others
Protein ID: WP_096922491.1
Location: 2897807..2898271 (465 bp)
Type: Others
Protein ID: WP_227406876.1
Location: 2898335..2898856 (522 bp)
Type: Others
Protein ID: WP_227406877.1
Location: 2898850..2899119 (270 bp)
Type: Others
Protein ID: WP_081139058.1
Location: 2901071..2901961 (891 bp)
Type: Others
Protein ID: WP_189463938.1
Location: 2902050..2902781 (732 bp)
Type: Others
Protein ID: WP_227406880.1
Location: 2902897..2903073 (177 bp)
Type: Others
Protein ID: Protein_2618
Location: 2903215..2903658 (444 bp)
Type: Others
Protein ID: WP_227406881.1
Location: 2903963..2904394 (432 bp)
Type: Others
Protein ID: WP_227406882.1
Location: 2904533..2905390 (858 bp)
Type: Others
Protein ID: WP_227406883.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LG409_RS13425 (LG409_13425)2895767..2896219-453WP_227406874.1N-acetyltransferase-
LG409_RS13430 (LG409_13430)2896227..2896649-423WP_227406875.1GFA family protein-
LG409_RS13435 (LG409_13435)2896688..2897158-471WP_193460799.1GNAT family N-acetyltransferase-
LG409_RS13440 (LG409_13440)2897182..2897709-528WP_096922491.1GNAT family N-acetyltransferase-
LG409_RS13445 (LG409_13445)2897807..2898271-465WP_227406876.1OsmC family protein-
LG409_RS13450 (LG409_13450)2898335..2898856-522WP_227406877.1DUF2442 domain-containing protein-
LG409_RS13455 (LG409_13455)2898850..2899119-270WP_081139058.1DUF4160 domain-containing protein-
LG409_RS13460 (LG409_13460)2899286..2900107+822WP_227406878.1aldo/keto reductase-
LG409_RS13465 (LG409_13465)2900271..2900522+252WP_227406879.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
LG409_RS13470 (LG409_13470)2900519..2900773+255WP_016914643.1Txe/YoeB family addiction module toxinToxin
LG409_RS13475 (LG409_13475)2901071..2901961-891WP_189463938.1DMT family transporter-
LG409_RS13480 (LG409_13480)2902050..2902781-732WP_227406880.1AraC family transcriptional regulator-
LG409_RS13485 (LG409_13485)2902897..2903073-177Protein_2618type II toxin-antitoxin system Phd/YefM family antitoxin-
LG409_RS13490 (LG409_13490)2903215..2903658-444WP_227406881.1hypothetical protein-
LG409_RS13495 (LG409_13495)2903963..2904394-432WP_227406882.1transposase-
LG409_RS13500 (LG409_13500)2904533..2905390-858WP_227406883.1HNH endonuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2900271..291255212281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10234.85 Da        Isoelectric Point: 9.8162

>T220516 WP_016914643.1 NZ_CP085143:2900519-2900773 [Halomonas sp. NyZ770]
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKEIKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIVYKVTDDALLVAQL
RYHY

Download         Length: 255 bp

>T220516 NZ_CP117053:c3869328-3868930 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9308.58 Da        Isoelectric Point: 4.6386

>AT220516 WP_227406879.1 NZ_CP085143:2900271-2900522 [Halomonas sp. NyZ770]
MDAISYTAARTNLAKTMERVCEDHSPVIITRNKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Download         Length: 252 bp

>AT220516 NZ_CP117053:c3869624-3869331 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A857GIF8

Antitoxin

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Source
ID
Structure
No matching records found

References