Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YoeB-YefM |
| Location | 2900271..2900773 | Replicon | chromosome |
| Accession | NZ_CP085143 | ||
| Organism | Halomonas sp. NyZ770 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A857GIF8 |
| Locus tag | LG409_RS13470 | Protein ID | WP_016914643.1 |
| Coordinates | 2900519..2900773 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LG409_RS13465 | Protein ID | WP_227406879.1 |
| Coordinates | 2900271..2900522 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LG409_RS13425 (LG409_13425) | 2895767..2896219 | - | 453 | WP_227406874.1 | N-acetyltransferase | - |
| LG409_RS13430 (LG409_13430) | 2896227..2896649 | - | 423 | WP_227406875.1 | GFA family protein | - |
| LG409_RS13435 (LG409_13435) | 2896688..2897158 | - | 471 | WP_193460799.1 | GNAT family N-acetyltransferase | - |
| LG409_RS13440 (LG409_13440) | 2897182..2897709 | - | 528 | WP_096922491.1 | GNAT family N-acetyltransferase | - |
| LG409_RS13445 (LG409_13445) | 2897807..2898271 | - | 465 | WP_227406876.1 | OsmC family protein | - |
| LG409_RS13450 (LG409_13450) | 2898335..2898856 | - | 522 | WP_227406877.1 | DUF2442 domain-containing protein | - |
| LG409_RS13455 (LG409_13455) | 2898850..2899119 | - | 270 | WP_081139058.1 | DUF4160 domain-containing protein | - |
| LG409_RS13460 (LG409_13460) | 2899286..2900107 | + | 822 | WP_227406878.1 | aldo/keto reductase | - |
| LG409_RS13465 (LG409_13465) | 2900271..2900522 | + | 252 | WP_227406879.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| LG409_RS13470 (LG409_13470) | 2900519..2900773 | + | 255 | WP_016914643.1 | Txe/YoeB family addiction module toxin | Toxin |
| LG409_RS13475 (LG409_13475) | 2901071..2901961 | - | 891 | WP_189463938.1 | DMT family transporter | - |
| LG409_RS13480 (LG409_13480) | 2902050..2902781 | - | 732 | WP_227406880.1 | AraC family transcriptional regulator | - |
| LG409_RS13485 (LG409_13485) | 2902897..2903073 | - | 177 | Protein_2618 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LG409_RS13490 (LG409_13490) | 2903215..2903658 | - | 444 | WP_227406881.1 | hypothetical protein | - |
| LG409_RS13495 (LG409_13495) | 2903963..2904394 | - | 432 | WP_227406882.1 | transposase | - |
| LG409_RS13500 (LG409_13500) | 2904533..2905390 | - | 858 | WP_227406883.1 | HNH endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2900271..2912552 | 12281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10234.85 Da Isoelectric Point: 9.8162
>T220516 WP_016914643.1 NZ_CP085143:2900519-2900773 [Halomonas sp. NyZ770]
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKEIKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIVYKVTDDALLVAQL
RYHY
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKEIKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIVYKVTDDALLVAQL
RYHY
Download Length: 255 bp
>T220516 NZ_CP117053:c3869328-3868930 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9308.58 Da Isoelectric Point: 4.6386
>AT220516 WP_227406879.1 NZ_CP085143:2900271-2900522 [Halomonas sp. NyZ770]
MDAISYTAARTNLAKTMERVCEDHSPVIITRNKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE
MDAISYTAARTNLAKTMERVCEDHSPVIITRNKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE
Download Length: 252 bp
>AT220516 NZ_CP117053:c3869624-3869331 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|