Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1455768..1456408 Replicon chromosome
Accession NZ_CP085143
Organism Halomonas sp. NyZ770

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LG409_RS06620 Protein ID WP_189462900.1
Coordinates 1455998..1456408 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H9I372
Locus tag LG409_RS06615 Protein ID WP_039177604.1
Coordinates 1455768..1455998 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG409_RS06595 (LG409_06595) 1450922..1451866 + 945 WP_039177612.1 phosphoserine phosphatase SerB -
LG409_RS06600 (LG409_06600) 1451955..1452797 - 843 WP_227407881.1 hypothetical protein -
LG409_RS06605 (LG409_06605) 1452959..1453855 + 897 WP_039177609.1 ion transporter -
LG409_RS06610 (LG409_06610) 1453869..1455548 + 1680 WP_096923195.1 2-isopropylmalate synthase -
LG409_RS06615 (LG409_06615) 1455768..1455998 + 231 WP_039177604.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LG409_RS06620 (LG409_06620) 1455998..1456408 + 411 WP_189462900.1 tRNA(fMet)-specific endonuclease VapC Toxin
LG409_RS06625 (LG409_06625) 1456516..1457568 + 1053 WP_227407882.1 hypothetical protein -
LG409_RS06630 (LG409_06630) 1457607..1459418 - 1812 WP_227407883.1 allophanate hydrolase -
LG409_RS06635 (LG409_06635) 1459457..1460173 - 717 WP_227407884.1 hypothetical protein -
LG409_RS06640 (LG409_06640) 1460170..1461249 - 1080 WP_227407885.1 2-oxoglutarate and iron-dependent oxygenase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15172.56 Da        Isoelectric Point: 7.9065

>T220513 WP_189462900.1 NZ_CP085143:1455998-1456408 [Halomonas sp. NyZ770]
MLKFMLDTNICIFTIKNRPQEVREAFKQHHGQLCISTVTLMELVYGAEKSAFPERNLATIEGFAARLDVLMYDEAAASHT
GQLRAEQAKVGKPIGPYDQMIAGHARSRGLILVTNNMREFKAVPGLRVEDWVGPGQ

Download         Length: 411 bp

>T220513 NZ_CP117053:2755973-2756080 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8432.45 Da        Isoelectric Point: 4.5358

>AT220513 WP_039177604.1 NZ_CP085143:1455768-1455998 [Halomonas sp. NyZ770]
MEQGAVFQSNRSQAVRLPKALALPEGVKRVDIVAIGRTRVISPAGEAWDSWFEGEGVSADFMSSREQPPEQERDLF

Download         Length: 231 bp

>AT220513 NZ_CP117053:c2755923-2755860 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References