Detailed information of TA system TA220513

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1455768..1456408
• Replicon: chromosome
• Accession: NZ_CP085143
• Organism: Halomonas sp. NyZ770

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LG409_RS06620
• Protein ID: WP_189462900.1
• Coordinates: 1455998..1456408 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8H9I372
• Locus tag: LG409_RS06615
• Protein ID: WP_039177604.1
• Coordinates: 1455768..1455998 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG409_RS06595 (LG409_06595)	1450922..1451866	+	945	WP_039177612.1	phosphoserine phosphatase SerB	-
LG409_RS06600 (LG409_06600)	1451955..1452797	-	843	WP_227407881.1	hypothetical protein	-
LG409_RS06605 (LG409_06605)	1452959..1453855	+	897	WP_039177609.1	ion transporter	-
LG409_RS06610 (LG409_06610)	1453869..1455548	+	1680	WP_096923195.1	2-isopropylmalate synthase	-
LG409_RS06615 (LG409_06615)	1455768..1455998	+	231	WP_039177604.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LG409_RS06620 (LG409_06620)	1455998..1456408	+	411	WP_189462900.1	tRNA(fMet)-specific endonuclease VapC	Toxin
LG409_RS06625 (LG409_06625)	1456516..1457568	+	1053	WP_227407882.1	hypothetical protein	-
LG409_RS06630 (LG409_06630)	1457607..1459418	-	1812	WP_227407883.1	allophanate hydrolase	-
LG409_RS06635 (LG409_06635)	1459457..1460173	-	717	WP_227407884.1	hypothetical protein	-
LG409_RS06640 (LG409_06640)	1460170..1461249	-	1080	WP_227407885.1	2-oxoglutarate and iron-dependent oxygenase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15172.56 Da
• Isoelectric Point: 7.9065

>T220513 WP_189462900.1 NZ_CP085143:1455998-1456408 [Halomonas sp. NyZ770]
MLKFMLDTNICIFTIKNRPQEVREAFKQHHGQLCISTVTLMELVYGAEKSAFPERNLATIEGFAARLDVLMYDEAAASHT
GQLRAEQAKVGKPIGPYDQMIAGHARSRGLILVTNNMREFKAVPGLRVEDWVGPGQ

Nucleotide

• Length: 411 bp

>T220513 NZ_CP117053:2755973-2756080 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8432.45 Da
• Isoelectric Point: 4.5358

>AT220513 WP_039177604.1 NZ_CP085143:1455768-1455998 [Halomonas sp. NyZ770]
MEQGAVFQSNRSQAVRLPKALALPEGVKRVDIVAIGRTRVISPAGEAWDSWFEGEGVSADFMSSREQPPEQERDLF

Nucleotide

• Length: 231 bp

>AT220513 NZ_CP117053:c2755923-2755860 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT