Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 6436680..6437351 Replicon chromosome
Accession NZ_CP085135
Organism Mesorhizobium sp. PAMC28654

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LGH82_RS31950 Protein ID WP_227346508.1
Coordinates 6436953..6437351 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LGH82_RS31945 Protein ID WP_227346507.1
Coordinates 6436680..6436952 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGH82_RS31920 (LGH82_31920) 6432018..6433004 + 987 WP_227346503.1 ABC transporter permease -
LGH82_RS31925 (LGH82_31925) 6433076..6433558 + 483 WP_227349741.1 gluconokinase -
LGH82_RS31930 (LGH82_31930) 6433541..6434695 - 1155 WP_227346504.1 hypothetical protein -
LGH82_RS31935 (LGH82_31935) 6434703..6435152 - 450 WP_227346505.1 Rrf2 family transcriptional regulator -
LGH82_RS31940 (LGH82_31940) 6435408..6436394 - 987 WP_227346506.1 sulfate ABC transporter substrate-binding protein -
LGH82_RS31945 (LGH82_31945) 6436680..6436952 + 273 WP_227346507.1 antitoxin Antitoxin
LGH82_RS31950 (LGH82_31950) 6436953..6437351 + 399 WP_227346508.1 type II toxin-antitoxin system VapC family toxin Toxin
LGH82_RS31955 (LGH82_31955) 6437366..6438406 - 1041 WP_227346509.1 sulfate/molybdate ABC transporter ATP-binding protein -
LGH82_RS31960 (LGH82_31960) 6438533..6439417 - 885 WP_227346511.1 sulfate ABC transporter permease subunit CysW -
LGH82_RS31965 (LGH82_31965) 6439410..6440261 - 852 WP_227346513.1 sulfate ABC transporter permease subunit CysT -
LGH82_RS31970 (LGH82_31970) 6440367..6441395 - 1029 WP_227346514.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(17-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14336.79 Da        Isoelectric Point: 5.1968

>T220512 WP_227346508.1 NZ_CP085135:6436953-6437351 [Mesorhizobium sp. PAMC28654]
MRFMLDTNIISDMIRNPTGKAVSAMLREGEAAVCTSIVVASELRYGCVKKGSSKLLKKVEELLAEIPVLPLDVPVDVQYG
ALRAELEGMGQPIGYNDLFIAAHACALGITLVTANTGEFRRIKDLSIENWLA

Download         Length: 399 bp

>T220512 NZ_CP117053:2755438-2755545 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10266.77 Da        Isoelectric Point: 4.7037

>AT220512 WP_227346507.1 NZ_CP085135:6436680-6436952 [Mesorhizobium sp. PAMC28654]
MPQRRHSPTPPKEARLFRNNRSQAVRIPVEFELPGEKVLISRDGDRLIIEPVRMAGLAALLAQWAKELPLGPEDDFPEID
DKPVEPEDIF

Download         Length: 273 bp

>AT220512 NZ_CP117053:c2755391-2755325 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References