Detailed information of TA system TA220507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 1851779..1852281
• Replicon: chromosome
• Accession: NZ_CP085096
• Organism: Aggregatibacter actinomycetemcomitans strain 4S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: LIN98_RS09190
• Protein ID: WP_005547296.1
• Coordinates: 1851779..1852030 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4W640
• Locus tag: LIN98_RS09195
• Protein ID: WP_005556313.1
• Coordinates: 1852027..1852281 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN98_RS09170	1847085..1848278	-	1194	WP_005556328.1	hypothetical protein	-
LIN98_RS09175	1848287..1849063	-	777	WP_005556324.1	glycosyltransferase family 25 protein	-
LIN98_RS09180	1849194..1850717	+	1524	WP_005556322.1	polysaccharide biosynthesis protein	-
LIN98_RS09185	1850714..1851670	+	957	WP_005556319.1	polysaccharide pyruvyl transferase family protein	-
LIN98_RS09190	1851779..1852030	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
LIN98_RS09195	1852027..1852281	+	255	WP_005556313.1	Txe/YoeB family addiction module toxin	Antitoxin
LIN98_RS09200	1852294..1853037	+	744	WP_005542222.1	YdcF family protein	-
LIN98_RS09205	1853214..1854041	+	828	WP_005556311.1	DNA ligase	-
LIN98_RS09210	1854174..1856348	-	2175	WP_249856112.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T220507 WP_005547296.1 NZ_CP085096:1851779-1852030 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T220507 NZ_CP117053:c1835524-1835147 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10217.71 Da
• Isoelectric Point: 8.8844

>AT220507 WP_005556313.1 NZ_CP085096:1852027-1852281 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT220507 NZ_CP117053:c1835982-1835614 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCTTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: S4W640