Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1588453..1589045 Replicon chromosome
Accession NZ_CP085096
Organism Aggregatibacter actinomycetemcomitans strain 4S

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LIN98_RS07940 Protein ID WP_014167707.1
Coordinates 1588746..1589045 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LIN98_RS07935 Protein ID WP_005568148.1
Coordinates 1588453..1588749 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN98_RS07905 1583529..1584326 - 798 WP_005568139.1 ABC transporter permease -
LIN98_RS07910 1584301..1584762 - 462 Protein_1525 extracellular solute-binding protein -
LIN98_RS07915 1584735..1585538 - 804 WP_005572988.1 aspartate-semialdehyde dehydrogenase -
LIN98_RS07920 1585599..1586078 + 480 WP_005545251.1 Cys-tRNA(Pro) deacylase -
LIN98_RS07925 1586382..1587779 - 1398 WP_005592819.1 MATE family efflux transporter -
LIN98_RS07930 1587806..1588420 + 615 WP_005568146.1 riboflavin synthase -
LIN98_RS07935 1588453..1588749 - 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
LIN98_RS07940 1588746..1589045 - 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN98_RS07945 1589213..1589515 + 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
LIN98_RS07950 1589588..1590064 - 477 WP_005572298.1 transcription elongation factor GreA -
LIN98_RS07955 1590224..1591666 + 1443 WP_050846335.1 serine-type D-Ala-D-Ala carboxypeptidase -
LIN98_RS07960 1591767..1592423 - 657 WP_005568155.1 GTP cyclohydrolase I FolE -
LIN98_RS07965 1592552..1593766 + 1215 WP_148326186.1 molybdopterin molybdotransferase MoeA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T220506 WP_014167707.1 NZ_CP085096:c1589045-1588746 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T220506 NZ_CP117053:1820001-1820255 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT220506 WP_005568148.1 NZ_CP085096:c1588749-1588453 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp

>AT220506 NZ_CP117053:1819753-1820004 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References