Detailed information of TA system TA220505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1550892..1551561
• Replicon: chromosome
• Accession: NZ_CP085096
• Organism: Aggregatibacter actinomycetemcomitans strain 4S

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LIN98_RS07760
• Protein ID: WP_005573679.1
• Coordinates: 1551223..1551561 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LIN98_RS07755
• Protein ID: WP_014167717.1
• Coordinates: 1550892..1551173 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN98_RS07740	1547370..1547852	-	483	WP_005544145.1	Dps family protein	-
LIN98_RS07745	1548061..1549221	+	1161	WP_249856103.1	EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit	-
LIN98_RS07750	1549231..1550748	+	1518	WP_005545812.1	DHA2 family efflux MFS transporter permease subunit	-
LIN98_RS07755	1550892..1551173	+	282	WP_014167717.1	helix-turn-helix domain-containing protein	Antitoxin
LIN98_RS07760	1551223..1551561	+	339	WP_005573679.1	HipA N-terminal domain-containing protein	Toxin
LIN98_RS07765	1551555..1551671	+	117	WP_005545808.1	hypothetical protein	-
LIN98_RS07770	1551671..1551793	+	123	WP_005573281.1	hypothetical protein	-
LIN98_RS07775	1551790..1552683	-	894	WP_005545804.1	hypothetical protein	-
LIN98_RS07780	1552750..1555614	-	2865	WP_053330372.1	valine--tRNA ligase	-
LIN98_RS07785	1555698..1556126	-	429	WP_080996242.1	DUF2726 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-88)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13104.85 Da
• Isoelectric Point: 8.6930

>T220505 WP_005573679.1 NZ_CP085096:1551223-1551561 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPDNEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Nucleotide

• Length: 339 bp

>T220505 NZ_CP117053:1819753-1820004 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10508.00 Da
• Isoelectric Point: 4.8356

>AT220505 WP_014167717.1 NZ_CP085096:1550892-1551173 [Aggregatibacter actinomycetemcomitans]
MVITTAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Nucleotide

• Length: 282 bp

>AT220505 NZ_CP117053:1820001-1820255 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA