Detailed information of TA system TA220503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1428423..1429076
• Replicon: chromosome
• Accession: NZ_CP085096
• Organism: Aggregatibacter actinomycetemcomitans strain 4S

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LIN98_RS07130
• Protein ID: WP_005578509.1
• Coordinates: 1428423..1428605 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LIN98_RS07135
• Protein ID: WP_014167744.1
• Coordinates: 1428657..1429076 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN98_RS07115	1425159..1425992	+	834	WP_249856098.1	integrase arm-type DNA-binding domain-containing protein	-
LIN98_RS07120	1426145..1426756	-	612	WP_005590093.1	DUF4376 domain-containing protein	-
LIN98_RS07125	1426756..1427922	-	1167	WP_005590091.1	phage tail protein	-
LIN98_RS07130	1428423..1428605	+	183	WP_005578509.1	type II toxin-antitoxin system HicA family toxin	Toxin
LIN98_RS07135	1428657..1429076	+	420	WP_014167744.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LIN98_RS07140	1429102..1429461	-	360	WP_005572282.1	hypothetical protein	-
LIN98_RS07145	1429458..1429565	-	108	Protein_1376	hypothetical protein	-
LIN98_RS07150	1429652..1429918	-	267	WP_061869853.1	hypothetical protein	-
LIN98_RS07155	1430156..1430380	+	225	WP_005545968.1	hypothetical protein	-
LIN98_RS07160	1430824..1431480	+	657	WP_005572271.1	P22AR C-terminal domain-containing protein	-
LIN98_RS07165	1431566..1431763	+	198	WP_005592077.1	hypothetical protein	-
LIN98_RS07170	1431736..1431945	+	210	WP_005592075.1	hypothetical protein	-
LIN98_RS07175	1431964..1432140	+	177	WP_005545966.1	AlpA family phage regulatory protein	-
LIN98_RS07180	1432645..1433595	-	951	WP_005545964.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1425174..1434202	9028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6952.13 Da
• Isoelectric Point: 10.1091

>T220503 WP_005578509.1 NZ_CP085096:1428423-1428605 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLEQGCKVEATKRGSHRKVTLNECQTVFPYHGSKEIGTGLVHKIKKDLNLK

Nucleotide

• Length: 183 bp

>T220503 NZ_CP117053:991036-991371 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15901.43 Da
• Isoelectric Point: 4.7175

>AT220503 WP_014167744.1 NZ_CP085096:1428657-1429076 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMASVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYMVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Nucleotide

• Length: 420 bp

>AT220503 NZ_CP117053:990788-991036 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA