Detailed information of TA system TA220502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1422827..1423377
• Replicon: chromosome
• Accession: NZ_CP085096
• Organism: Aggregatibacter actinomycetemcomitans strain 4S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LIN98_RS07105
• Protein ID: WP_014167746.1
• Coordinates: 1423111..1423377 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: LIN98_RS07100
• Protein ID: WP_005539223.1
• Coordinates: 1422827..1423099 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN98_RS07080	1418806..1420302	-	1497	WP_005569410.1	transcription termination factor NusA	-
LIN98_RS07085	1420326..1420781	-	456	WP_005569409.1	ribosome maturation factor RimP	-
LIN98_RS07095	1421220..1422572	+	1353	WP_005545994.1	anaerobic C4-dicarboxylate transporter DcuC	-
LIN98_RS07100	1422827..1423099	+	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LIN98_RS07105	1423111..1423377	+	267	WP_014167746.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LIN98_RS07110	1423409..1424968	+	1560	WP_005590096.1	glutamine-hydrolyzing GMP synthase	-
LIN98_RS07115	1425159..1425992	+	834	WP_249856098.1	integrase arm-type DNA-binding domain-containing protein	-
LIN98_RS07120	1426145..1426756	-	612	WP_005590093.1	DUF4376 domain-containing protein	-
LIN98_RS07125	1426756..1427922	-	1167	WP_005590091.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T220502 WP_014167746.1 NZ_CP085096:1423111-1423377 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKIPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T220502 NZ_CP117053:834484-834891 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT220502 WP_005539223.1 NZ_CP085096:1422827-1423099 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT220502 NZ_CP117053:834237-834503 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: X2JQ67