Detailed information of TA system TA220500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1985373..1985907
• Replicon: chromosome
• Accession: NZ_CP085095
• Organism: Aggregatibacter actinomycetemcomitans strain 5R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FYB7
• Locus tag: LIN97_RS09945
• Protein ID: WP_005540089.1
• Coordinates: 1985617..1985907 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN97_RS09940
• Protein ID: WP_005545663.1
• Coordinates: 1985373..1985627 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN97_RS09895	1981219..1981305	+	87	Protein_1914	MerR family DNA-binding transcriptional regulator	-
LIN97_RS09900	1981532..1981879	+	348	Protein_1915	relaxase/mobilization nuclease domain-containing protein	-
LIN97_RS09905	1981887..1981982	+	96	Protein_1916	MbeB family mobilization protein	-
LIN97_RS09910	1982109..1982195	+	87	Protein_1917	aminotransferase	-
LIN97_RS09915	1982206..1983537	+	1332	WP_249849276.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
LIN97_RS09920	1983625..1984092	-	468	WP_005565412.1	ribonuclease HI	-
LIN97_RS09925	1984160..1984921	+	762	WP_005567590.1	DNA polymerase III subunit epsilon	-
LIN97_RS09940	1985373..1985627	+	255	WP_005545663.1	stability protein StbD	Antitoxin
LIN97_RS09945	1985617..1985907	+	291	WP_005540089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN97_RS09950	1985964..1986305	-	342	WP_014167925.1	cupin domain-containing protein	-
LIN97_RS09955	1986646..1987098	+	453	WP_006710245.1	50S ribosomal protein L11 methyltransferase	-
LIN97_RS09960	1987269..1988657	+	1389	WP_005567594.1	tRNA 5-hydroxyuridine modification protein YegQ	-
LIN97_RS09965	1988954..1990045	+	1092	WP_014167926.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11509.34 Da
• Isoelectric Point: 10.7396

>T220500 WP_005540089.1 NZ_CP085095:1985617-1985907 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T220500 NZ_CP117053:c608781-608317 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT220500 WP_005545663.1 NZ_CP085095:1985373-1985627 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Nucleotide

• Length: 255 bp

>AT220500 NZ_CP117053:c609116-608781 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A142FYB7