Detailed information of TA system TA220498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 1891267..1891769
• Replicon: chromosome
• Accession: NZ_CP085095
• Organism: Aggregatibacter actinomycetemcomitans strain 5R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: LIN97_RS09525
• Protein ID: WP_005547296.1
• Coordinates: 1891267..1891518 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4W640
• Locus tag: LIN97_RS09530
• Protein ID: WP_005556313.1
• Coordinates: 1891515..1891769 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN97_RS09505	1886573..1887766	-	1194	WP_005556328.1	hypothetical protein	-
LIN97_RS09510	1887775..1888551	-	777	WP_005556324.1	glycosyltransferase family 25 protein	-
LIN97_RS09515	1888682..1890205	+	1524	WP_005567290.1	polysaccharide biosynthesis protein	-
LIN97_RS09520	1890202..1891158	+	957	WP_005556319.1	polysaccharide pyruvyl transferase family protein	-
LIN97_RS09525	1891267..1891518	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
LIN97_RS09530	1891515..1891769	+	255	WP_005556313.1	Txe/YoeB family addiction module toxin	Antitoxin
LIN97_RS09535	1891782..1892525	+	744	WP_005542222.1	YdcF family protein	-
LIN97_RS09540	1892702..1893529	+	828	WP_249849272.1	DNA ligase	-
LIN97_RS09545	1893662..1895836	-	2175	WP_005556309.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	wbtL / lsgF / lsgE / lsgD	1855866..1912594	56728

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T220498 WP_005547296.1 NZ_CP085095:1891267-1891518 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T220498 NZ_CP117050:152234-152650 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10217.71 Da
• Isoelectric Point: 8.8844

>AT220498 WP_005556313.1 NZ_CP085095:1891515-1891769 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT220498 NZ_CP117050:152007-152237 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: S4W640