Detailed information of TA system TA220495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1325194..1325847
• Replicon: chromosome
• Accession: NZ_CP085095
• Organism: Aggregatibacter actinomycetemcomitans strain 5R

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LIN97_RS06880
• Protein ID: WP_005567475.1
• Coordinates: 1325665..1325847 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LIN97_RS06875
• Protein ID: WP_005567474.1
• Coordinates: 1325194..1325613 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN97_RS06835	1320541..1321062	-	522	WP_233115373.1	hypothetical protein	-
LIN97_RS06840	1321644..1322552	-	909	WP_249849249.1	hypothetical protein	-
LIN97_RS06845	1322643..1323308	-	666	WP_005567468.1	S24 family peptidase	-
LIN97_RS06850	1323409..1323648	+	240	WP_005567469.1	hypothetical protein	-
LIN97_RS06855	1323675..1324145	+	471	WP_005567471.1	hypothetical protein	-
LIN97_RS06860	1324142..1324360	+	219	WP_005579230.1	hypothetical protein	-
LIN97_RS06865	1324363..1324812	+	450	WP_005567472.1	HD domain-containing protein	-
LIN97_RS06870	1324809..1325168	+	360	WP_005567473.1	hypothetical protein	-
LIN97_RS06875	1325194..1325613	-	420	WP_005567474.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LIN97_RS06880	1325665..1325847	-	183	WP_005567475.1	type II toxin-antitoxin system HicA family toxin	Toxin
LIN97_RS06885	1326102..1327415	+	1314	WP_233119046.1	DUF4041 domain-containing protein	-
LIN97_RS06890	1327581..1328396	-	816	WP_005567483.1	DUF4102 domain-containing protein	-
LIN97_RS06895	1328587..1330146	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
LIN97_RS06900	1330178..1330444	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
LIN97_RS06905	1330456..1330728	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1317598..1328381	10783

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6938.10 Da
• Isoelectric Point: 10.1091

>T220495 WP_005567475.1 NZ_CP085095:c1325847-1325665 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLEQGCKVEATKRGSHRKVTLNDCQTVFPYHGSKEIGTGLVHKIKKDLNLK

Nucleotide

• Length: 183 bp

>T220495 NZ_CP117049:c4507826-4507653 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15899.39 Da
• Isoelectric Point: 4.7175

>AT220495 WP_005567474.1 NZ_CP085095:c1325613-1325194 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMVSVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYTVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Nucleotide

• Length: 420 bp

>AT220495 NZ_CP117049:c4508150-4507854 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG