Detailed information of TA system TA220493

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1200583..1201252
• Replicon: chromosome
• Accession: NZ_CP085095
• Organism: Aggregatibacter actinomycetemcomitans strain 5R

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LIN97_RS06240
• Protein ID: WP_233119039.1
• Coordinates: 1200583..1200921 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LIN97_RS06245
• Protein ID: WP_014167717.1
• Coordinates: 1200971..1201252 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN97_RS06215	1196018..1196446	+	429	WP_019518326.1	DUF2726 domain-containing protein	-
LIN97_RS06220	1196530..1199394	+	2865	WP_233119040.1	valine--tRNA ligase	-
LIN97_RS06225	1199461..1200354	+	894	WP_005545804.1	hypothetical protein	-
LIN97_RS06230	1200351..1200473	-	123	WP_005573281.1	hypothetical protein	-
LIN97_RS06235	1200473..1200589	-	117	WP_005545808.1	hypothetical protein	-
LIN97_RS06240	1200583..1200921	-	339	WP_233119039.1	HipA N-terminal domain-containing protein	Toxin
LIN97_RS06245	1200971..1201252	-	282	WP_014167717.1	helix-turn-helix domain-containing protein	Antitoxin
LIN97_RS06250	1201396..1202913	-	1518	WP_005545812.1	DHA2 family efflux MFS transporter permease subunit	-
LIN97_RS06255	1202923..1204083	-	1161	WP_005545814.1	EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit	-
LIN97_RS06260	1204292..1204774	+	483	WP_005544145.1	Dps family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-88)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13134.88 Da
• Isoelectric Point: 8.6930

>T220493 WP_233119039.1 NZ_CP085095:c1200921-1200583 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPDNEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYTEPLNDKKCKTC

Nucleotide

• Length: 339 bp

>T220493 NZ_CP117049:4283556-4283813 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10508.00 Da
• Isoelectric Point: 4.8356

>AT220493 WP_014167717.1 NZ_CP085095:c1201252-1200971 [Aggregatibacter actinomycetemcomitans]
MVITTAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Nucleotide

• Length: 282 bp

>AT220493 NZ_CP117049:4283825-4284370 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA