Detailed information of TA system TA220492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 1163098..1163690
• Replicon: chromosome
• Accession: NZ_CP085095
• Organism: Aggregatibacter actinomycetemcomitans strain 5R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LIN97_RS06060
• Protein ID: WP_014167707.1
• Coordinates: 1163098..1163397 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN97_RS06065
• Protein ID: WP_005568148.1
• Coordinates: 1163394..1163690 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN97_RS06035	1158377..1159591	-	1215	WP_014167705.1	molybdopterin molybdotransferase MoeA	-
LIN97_RS06040	1159720..1160376	+	657	WP_005568155.1	GTP cyclohydrolase I FolE	-
LIN97_RS06045	1160477..1161919	-	1443	WP_005568153.1	serine-type D-Ala-D-Ala carboxypeptidase	-
LIN97_RS06050	1162079..1162555	+	477	WP_005568152.1	transcription elongation factor GreA	-
LIN97_RS06055	1162628..1162930	-	303	WP_005568150.1	ribosome assembly RNA-binding protein YhbY	-
LIN97_RS06060	1163098..1163397	+	300	WP_014167707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN97_RS06065	1163394..1163690	+	297	WP_005568148.1	putative addiction module antidote protein	Antitoxin
LIN97_RS06070	1163723..1164337	-	615	WP_005568146.1	riboflavin synthase	-
LIN97_RS06075	1164364..1165761	+	1398	WP_005568144.1	MATE family efflux transporter	-
LIN97_RS06080	1166065..1166544	-	480	WP_005545251.1	Cys-tRNA(Pro) deacylase	-
LIN97_RS06085	1166605..1167408	+	804	WP_233112656.1	oxidoreductase	-
LIN97_RS06090	1167381..1167842	+	462	Protein_1177	extracellular solute-binding protein	-
LIN97_RS06095	1167817..1168614	+	798	WP_005568139.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-92)

Antitoxin

• Uncharacterized protein HI1420 (5-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11406.53 Da
• Isoelectric Point: 10.6671

>T220492 WP_014167707.1 NZ_CP085095:1163098-1163397 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Nucleotide

• Length: 300 bp

>T220492 NZ_CP117049:4228829-4229170 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10939.44 Da
• Isoelectric Point: 4.4155

>AT220492 WP_005568148.1 NZ_CP085095:1163394-1163690 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Nucleotide

• Length: 297 bp

>AT220492 NZ_CP117049:c4228834-4228758 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT