Detailed information of TA system TA220491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1985383..1985917
• Replicon: chromosome
• Accession: NZ_CP085094
• Organism: Aggregatibacter actinomycetemcomitans strain 5S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FYB7
• Locus tag: LIN95_RS09940
• Protein ID: WP_005540089.1
• Coordinates: 1985627..1985917 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN95_RS09935
• Protein ID: WP_005545663.1
• Coordinates: 1985383..1985637 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN95_RS09890	1981229..1981315	+	87	Protein_1913	MerR family DNA-binding transcriptional regulator	-
LIN95_RS09895	1981542..1981889	+	348	Protein_1914	relaxase/mobilization nuclease domain-containing protein	-
LIN95_RS09900	1981897..1981992	+	96	Protein_1915	MbeB family mobilization protein	-
LIN95_RS09905	1982119..1982205	+	87	Protein_1916	aminotransferase	-
LIN95_RS09910	1982216..1983547	+	1332	WP_249849276.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
LIN95_RS09915	1983635..1984102	-	468	WP_005565412.1	ribonuclease HI	-
LIN95_RS09920	1984170..1984931	+	762	WP_005567590.1	DNA polymerase III subunit epsilon	-
LIN95_RS09935	1985383..1985637	+	255	WP_005545663.1	stability protein StbD	Antitoxin
LIN95_RS09940	1985627..1985917	+	291	WP_005540089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN95_RS09945	1985974..1986315	-	342	WP_014167925.1	cupin domain-containing protein	-
LIN95_RS09950	1986656..1987108	+	453	WP_006710245.1	50S ribosomal protein L11 methyltransferase	-
LIN95_RS09955	1987279..1988667	+	1389	WP_005567594.1	tRNA 5-hydroxyuridine modification protein YegQ	-
LIN95_RS09960	1988964..1990055	+	1092	WP_014167926.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11509.34 Da
• Isoelectric Point: 10.7396

>T220491 WP_005540089.1 NZ_CP085094:1985627-1985917 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T220491 NZ_CP117049:3875390-3875668 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT220491 WP_005545663.1 NZ_CP085094:1985383-1985637 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Nucleotide

• Length: 255 bp

>AT220491 NZ_CP117049:3875127-3875387 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: A0A142FYB7