220489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YefM-YoeB
Location 1891277..1891779 Replicon chromosome
Accession NZ_CP085094
Organism Aggregatibacter actinomycetemcomitans strain 5S

Toxin (Protein)


Gene name relE Uniprot ID X2JX79
Locus tag LIN95_RS09520 Protein ID WP_005547296.1
Coordinates 1891277..1891528 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S4W640
Locus tag LIN95_RS09525 Protein ID WP_005556313.1
Coordinates 1891525..1891779 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN95_RS09500 1886583..1887776 - 1194 WP_005556328.1 hypothetical protein -
LIN95_RS09505 1887785..1888561 - 777 WP_005556324.1 glycosyltransferase family 25 protein -
LIN95_RS09510 1888692..1890215 + 1524 WP_005567290.1 polysaccharide biosynthesis protein -
LIN95_RS09515 1890212..1891168 + 957 WP_005556319.1 polysaccharide pyruvyl transferase family protein -
LIN95_RS09520 1891277..1891528 + 252 WP_005547296.1 type II toxin-antitoxin system prevent-host-death family antitoxin Toxin
LIN95_RS09525 1891525..1891779 + 255 WP_005556313.1 Txe/YoeB family addiction module toxin Antitoxin
LIN95_RS09530 1891792..1892535 + 744 WP_005542222.1 YdcF family protein -
LIN95_RS09535 1892712..1893539 + 828 WP_249849272.1 DNA ligase -
LIN95_RS09540 1893672..1895846 - 2175 WP_005556309.1 DNA helicase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(1-84)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9394.66 Da        Isoelectric Point: 5.0637

>T220489 WP_005547296.1 NZ_CP085094:1891277-1891528 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>T220489 NZ_CP117049:c3809778-3809401 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGAGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10217.71 Da        Isoelectric Point: 8.8844

>AT220489 WP_005556313.1 NZ_CP085094:1891525-1891779 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>AT220489 NZ_CP117049:c3810236-3809868 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCAGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JX79

Antitoxin

Source ID Structure
AlphaFold DB S4W640

References