220487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1330178..1330728 Replicon chromosome
Accession NZ_CP085094
Organism Aggregatibacter actinomycetemcomitans strain 5S

Toxin (Protein)


Gene name relE Uniprot ID X2JVL6
Locus tag LIN95_RS06900 Protein ID WP_005545988.1
Coordinates 1330178..1330444 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag LIN95_RS06905 Protein ID WP_005539223.1
Coordinates 1330456..1330728 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN95_RS06875 1325194..1325613 - 420 WP_005567474.1 type II toxin-antitoxin system HicB family antitoxin -
LIN95_RS06880 1325665..1325847 - 183 WP_005567475.1 type II toxin-antitoxin system HicA family toxin -
LIN95_RS06885 1326102..1327415 + 1314 WP_233119046.1 DUF4041 domain-containing protein -
LIN95_RS06890 1327581..1328396 - 816 WP_005567483.1 DUF4102 domain-containing protein -
LIN95_RS06895 1328587..1330146 - 1560 WP_005545986.1 glutamine-hydrolyzing GMP synthase -
LIN95_RS06900 1330178..1330444 - 267 WP_005545988.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LIN95_RS06905 1330456..1330728 - 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LIN95_RS06910 1330983..1332335 - 1353 WP_005545994.1 anaerobic C4-dicarboxylate transporter DcuC -
LIN95_RS06920 1332774..1333229 + 456 WP_005545995.1 ribosome maturation factor RimP -
LIN95_RS06925 1333253..1334749 + 1497 WP_005567486.1 transcription termination factor NusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10516.05 Da        Isoelectric Point: 7.2393

>T220487 WP_005545988.1 NZ_CP085094:c1330444-1330178 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T220487 NZ_CP117049:2755973-2756080 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT220487 WP_005539223.1 NZ_CP085094:c1330728-1330456 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp

>AT220487 NZ_CP117049:c2755923-2755860 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JVL6

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References