Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1163098..1163690 Replicon chromosome
Accession NZ_CP085094
Organism Aggregatibacter actinomycetemcomitans strain 5S

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LIN95_RS06060 Protein ID WP_014167707.1
Coordinates 1163098..1163397 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LIN95_RS06065 Protein ID WP_005568148.1
Coordinates 1163394..1163690 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN95_RS06035 1158377..1159591 - 1215 WP_014167705.1 molybdopterin molybdotransferase MoeA -
LIN95_RS06040 1159720..1160376 + 657 WP_005568155.1 GTP cyclohydrolase I FolE -
LIN95_RS06045 1160477..1161919 - 1443 WP_005568153.1 serine-type D-Ala-D-Ala carboxypeptidase -
LIN95_RS06050 1162079..1162555 + 477 WP_005568152.1 transcription elongation factor GreA -
LIN95_RS06055 1162628..1162930 - 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
LIN95_RS06060 1163098..1163397 + 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN95_RS06065 1163394..1163690 + 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
LIN95_RS06070 1163723..1164337 - 615 WP_005568146.1 riboflavin synthase -
LIN95_RS06075 1164364..1165761 + 1398 WP_005568144.1 MATE family efflux transporter -
LIN95_RS06080 1166065..1166544 - 480 WP_005545251.1 Cys-tRNA(Pro) deacylase -
LIN95_RS06085 1166605..1167408 + 804 WP_233112656.1 oxidoreductase -
LIN95_RS06090 1167381..1167842 + 462 Protein_1177 extracellular solute-binding protein -
LIN95_RS06095 1167817..1168614 + 798 WP_005568139.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T220483 WP_014167707.1 NZ_CP085094:1163098-1163397 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T220483 NZ_CP117049:2450175-2451497 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT220483 WP_005568148.1 NZ_CP085094:1163394-1163690 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp

>AT220483 NZ_CP117049:2449909-2450175 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References