Detailed information of TA system TA220482

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 2000350..2000884
• Replicon: chromosome
• Accession: NZ_CP085093
• Organism: Aggregatibacter actinomycetemcomitans strain 23S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FYB7
• Locus tag: LIN99_RS10065
• Protein ID: WP_005540089.1
• Coordinates: 2000594..2000884 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN99_RS10060
• Protein ID: WP_005545663.1
• Coordinates: 2000350..2000604 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN99_RS10015	1996196..1996282	+	87	Protein_1938	MerR family DNA-binding transcriptional regulator	-
LIN99_RS10020	1996509..1996856	+	348	Protein_1939	relaxase/mobilization nuclease domain-containing protein	-
LIN99_RS10025	1996864..1996959	+	96	Protein_1940	MbeB family mobilization protein	-
LIN99_RS10030	1997086..1997172	+	87	Protein_1941	aminotransferase	-
LIN99_RS10035	1997183..1998514	+	1332	WP_005594223.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
LIN99_RS10040	1998602..1999069	-	468	WP_005565412.1	ribonuclease HI	-
LIN99_RS10045	1999137..1999898	+	762	WP_005567590.1	DNA polymerase III subunit epsilon	-
LIN99_RS10060	2000350..2000604	+	255	WP_005545663.1	stability protein StbD	Antitoxin
LIN99_RS10065	2000594..2000884	+	291	WP_005540089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN99_RS10070	2000941..2001282	-	342	WP_014167925.1	cupin domain-containing protein	-
LIN99_RS10075	2001623..2002075	+	453	WP_006710245.1	50S ribosomal protein L11 methyltransferase	-
LIN99_RS10080	2002246..2003634	+	1389	WP_005567594.1	tRNA 5-hydroxyuridine modification protein YegQ	-
LIN99_RS10085	2003931..2005022	+	1092	WP_014167926.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11509.34 Da
• Isoelectric Point: 10.7396

>T220482 WP_005540089.1 NZ_CP085093:2000594-2000884 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T220482 NZ_CP117049:2136095-2136198 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT220482 WP_005545663.1 NZ_CP085093:2000350-2000604 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Nucleotide

• Length: 255 bp

>AT220482 NZ_CP117049:c2136236-2135965 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A142FYB7