Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | relBE/YafQ-RelB |
Location | 1330082..1330632 | Replicon | chromosome |
Accession | NZ_CP085093 | ||
Organism | Aggregatibacter actinomycetemcomitans strain 23S |
Toxin (Protein)
Gene name | relE | Uniprot ID | X2JVL6 |
Locus tag | LIN99_RS06900 | Protein ID | WP_005545988.1 |
Coordinates | 1330082..1330348 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | X2JQ67 |
Locus tag | LIN99_RS06905 | Protein ID | WP_005539223.1 |
Coordinates | 1330360..1330632 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LIN99_RS06875 | 1325098..1325517 | - | 420 | WP_005567474.1 | type II toxin-antitoxin system HicB family antitoxin | - |
LIN99_RS06880 | 1325569..1325751 | - | 183 | WP_005567475.1 | type II toxin-antitoxin system HicA family toxin | - |
LIN99_RS06885 | 1326006..1327319 | + | 1314 | WP_233119046.1 | DUF4041 domain-containing protein | - |
LIN99_RS06890 | 1327485..1328300 | - | 816 | WP_005567483.1 | DUF4102 domain-containing protein | - |
LIN99_RS06895 | 1328491..1330050 | - | 1560 | WP_005545986.1 | glutamine-hydrolyzing GMP synthase | - |
LIN99_RS06900 | 1330082..1330348 | - | 267 | WP_005545988.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
LIN99_RS06905 | 1330360..1330632 | - | 273 | WP_005539223.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
LIN99_RS06910 | 1330887..1332239 | - | 1353 | WP_005545994.1 | anaerobic C4-dicarboxylate transporter DcuC | - |
LIN99_RS06920 | 1332678..1333133 | + | 456 | WP_005545995.1 | ribosome maturation factor RimP | - |
LIN99_RS06925 | 1333157..1334653 | + | 1497 | WP_005567486.1 | transcription termination factor NusA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10516.05 Da Isoelectric Point: 7.2393
>T220478 WP_005545988.1 NZ_CP085093:c1330348-1330082 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK
Download Length: 267 bp
>T220478 NZ_CP117049:1066175-1066486 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10147.52 Da Isoelectric Point: 6.2633
>AT220478 WP_005539223.1 NZ_CP085093:c1330632-1330360 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK
Download Length: 273 bp
>AT220478 NZ_CP117049:1066483-1066902 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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