Detailed information of TA system TA220478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1330082..1330632
• Replicon: chromosome
• Accession: NZ_CP085093
• Organism: Aggregatibacter actinomycetemcomitans strain 23S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: LIN99_RS06900
• Protein ID: WP_005545988.1
• Coordinates: 1330082..1330348 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: LIN99_RS06905
• Protein ID: WP_005539223.1
• Coordinates: 1330360..1330632 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN99_RS06875	1325098..1325517	-	420	WP_005567474.1	type II toxin-antitoxin system HicB family antitoxin	-
LIN99_RS06880	1325569..1325751	-	183	WP_005567475.1	type II toxin-antitoxin system HicA family toxin	-
LIN99_RS06885	1326006..1327319	+	1314	WP_233119046.1	DUF4041 domain-containing protein	-
LIN99_RS06890	1327485..1328300	-	816	WP_005567483.1	DUF4102 domain-containing protein	-
LIN99_RS06895	1328491..1330050	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
LIN99_RS06900	1330082..1330348	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LIN99_RS06905	1330360..1330632	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LIN99_RS06910	1330887..1332239	-	1353	WP_005545994.1	anaerobic C4-dicarboxylate transporter DcuC	-
LIN99_RS06920	1332678..1333133	+	456	WP_005545995.1	ribosome maturation factor RimP	-
LIN99_RS06925	1333157..1334653	+	1497	WP_005567486.1	transcription termination factor NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T220478 WP_005545988.1 NZ_CP085093:c1330348-1330082 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T220478 NZ_CP117049:1066175-1066486 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT220478 WP_005539223.1 NZ_CP085093:c1330632-1330360 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT220478 NZ_CP117049:1066483-1066902 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Toxin

• AlphaFold DB: X2JVL6

Antitoxin

• AlphaFold DB: X2JQ67