Detailed information of TA system TA220477

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1325098..1325751
• Replicon: chromosome
• Accession: NZ_CP085093
• Organism: Aggregatibacter actinomycetemcomitans strain 23S

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LIN99_RS06880
• Protein ID: WP_005567475.1
• Coordinates: 1325569..1325751 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LIN99_RS06875
• Protein ID: WP_005567474.1
• Coordinates: 1325098..1325517 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN99_RS06835	1320445..1320966	-	522	WP_233115373.1	hypothetical protein	-
LIN99_RS06840	1321548..1322456	-	909	WP_233115372.1	hypothetical protein	-
LIN99_RS06845	1322547..1323212	-	666	WP_005567468.1	S24 family peptidase	-
LIN99_RS06850	1323313..1323552	+	240	WP_005567469.1	hypothetical protein	-
LIN99_RS06855	1323579..1324049	+	471	WP_005567471.1	hypothetical protein	-
LIN99_RS06860	1324046..1324264	+	219	WP_005579230.1	hypothetical protein	-
LIN99_RS06865	1324267..1324716	+	450	WP_005567472.1	HD domain-containing protein	-
LIN99_RS06870	1324713..1325072	+	360	WP_005567473.1	hypothetical protein	-
LIN99_RS06875	1325098..1325517	-	420	WP_005567474.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LIN99_RS06880	1325569..1325751	-	183	WP_005567475.1	type II toxin-antitoxin system HicA family toxin	Toxin
LIN99_RS06885	1326006..1327319	+	1314	WP_233119046.1	DUF4041 domain-containing protein	-
LIN99_RS06890	1327485..1328300	-	816	WP_005567483.1	DUF4102 domain-containing protein	-
LIN99_RS06895	1328491..1330050	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
LIN99_RS06900	1330082..1330348	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
LIN99_RS06905	1330360..1330632	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1317502..1328285	10783

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6938.10 Da
• Isoelectric Point: 10.1091

>T220477 WP_005567475.1 NZ_CP085093:c1325751-1325569 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLEQGCKVEATKRGSHRKVTLNDCQTVFPYHGSKEIGTGLVHKIKKDLNLK

Nucleotide

• Length: 183 bp

>T220477 NZ_CP117049:991036-991371 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15899.39 Da
• Isoelectric Point: 4.7175

>AT220477 WP_005567474.1 NZ_CP085093:c1325517-1325098 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMVSVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYTVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Nucleotide

• Length: 420 bp

>AT220477 NZ_CP117049:990788-991036 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA