220475

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1200555..1201224 Replicon chromosome
Accession NZ_CP085093
Organism Aggregatibacter actinomycetemcomitans strain 23S

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LIN99_RS06240 Protein ID WP_233119039.1
Coordinates 1200555..1200893 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LIN99_RS06245 Protein ID WP_014167717.1
Coordinates 1200943..1201224 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN99_RS06210 1195990..1196418 + 429 WP_019518326.1 DUF2726 domain-containing protein -
LIN99_RS06215 1196502..1199366 + 2865 WP_233119040.1 valine--tRNA ligase -
LIN99_RS06220 1199433..1200014 + 582 WP_249850124.1 hypothetical protein -
LIN99_RS06225 1200027..1200326 + 300 WP_249850125.1 hypothetical protein -
LIN99_RS06230 1200323..1200445 - 123 WP_005573281.1 hypothetical protein -
LIN99_RS06235 1200445..1200561 - 117 WP_005545808.1 hypothetical protein -
LIN99_RS06240 1200555..1200893 - 339 WP_233119039.1 HipA N-terminal domain-containing protein Toxin
LIN99_RS06245 1200943..1201224 - 282 WP_014167717.1 helix-turn-helix domain-containing protein Antitoxin
LIN99_RS06250 1201368..1202885 - 1518 WP_005545812.1 DHA2 family efflux MFS transporter permease subunit -
LIN99_RS06255 1202895..1204055 - 1161 WP_005545814.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
LIN99_RS06260 1204264..1204746 + 483 WP_005544145.1 Dps family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13134.88 Da        Isoelectric Point: 8.6930

>T220475 WP_233119039.1 NZ_CP085093:c1200893-1200555 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPDNEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYTEPLNDKKCKTC

Download         Length: 339 bp

>T220475 NZ_CP117049:726960-727256 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10508.00 Da        Isoelectric Point: 4.8356

>AT220475 WP_014167717.1 NZ_CP085093:c1201224-1200943 [Aggregatibacter actinomycetemcomitans]
MVITTAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Download         Length: 282 bp

>AT220475 NZ_CP117049:727258-727653 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References