Detailed information of TA system TA220474

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 1163070..1163662
• Replicon: chromosome
• Accession: NZ_CP085093
• Organism: Aggregatibacter actinomycetemcomitans strain 23S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LIN99_RS06055
• Protein ID: WP_014167707.1
• Coordinates: 1163070..1163369 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN99_RS06060
• Protein ID: WP_005568148.1
• Coordinates: 1163366..1163662 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN99_RS06030	1158349..1159563	-	1215	WP_014167705.1	molybdopterin molybdotransferase MoeA	-
LIN99_RS06035	1159692..1160348	+	657	WP_005568155.1	GTP cyclohydrolase I FolE	-
LIN99_RS06040	1160449..1161891	-	1443	WP_005568153.1	serine-type D-Ala-D-Ala carboxypeptidase	-
LIN99_RS06045	1162051..1162527	+	477	WP_005568152.1	transcription elongation factor GreA	-
LIN99_RS06050	1162600..1162902	-	303	WP_005568150.1	ribosome assembly RNA-binding protein YhbY	-
LIN99_RS06055	1163070..1163369	+	300	WP_014167707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN99_RS06060	1163366..1163662	+	297	WP_005568148.1	putative addiction module antidote protein	Antitoxin
LIN99_RS06065	1163695..1164309	-	615	WP_005568146.1	riboflavin synthase	-
LIN99_RS06070	1164336..1165733	+	1398	WP_005568144.1	MATE family efflux transporter	-
LIN99_RS06075	1166037..1166516	-	480	WP_005545251.1	Cys-tRNA(Pro) deacylase	-
LIN99_RS06080	1166577..1167380	+	804	WP_233112656.1	oxidoreductase	-
LIN99_RS06085	1167353..1167814	+	462	Protein_1176	extracellular solute-binding protein	-
LIN99_RS06090	1167789..1168586	+	798	WP_005568139.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-92)

Antitoxin

• Uncharacterized protein HI1420 (5-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11406.53 Da
• Isoelectric Point: 10.6671

>T220474 WP_014167707.1 NZ_CP085093:1163070-1163369 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Nucleotide

• Length: 300 bp

>T220474 NZ_CP117049:c608781-608317 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10939.44 Da
• Isoelectric Point: 4.4155

>AT220474 WP_005568148.1 NZ_CP085093:1163366-1163662 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Nucleotide

• Length: 297 bp

>AT220474 NZ_CP117049:c609116-608781 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA