220473

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1949811..1950345 Replicon chromosome
Accession NZ_CP085092
Organism Aggregatibacter actinomycetemcomitans strain 30R

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag LIN94_RS09590 Protein ID WP_005540089.1
Coordinates 1950055..1950345 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LIN94_RS09585 Protein ID WP_005545663.1
Coordinates 1949811..1950065 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN94_RS09555 1945536..1946633 + 1098 WP_005567586.1 histidinol-phosphate transaminase -
LIN94_RS09560 1946644..1947975 + 1332 WP_005594223.1 3-phosphoshikimate 1-carboxyvinyltransferase -
LIN94_RS09565 1948063..1948530 - 468 WP_005565412.1 ribonuclease HI -
LIN94_RS09570 1948598..1949359 + 762 WP_005567590.1 DNA polymerase III subunit epsilon -
LIN94_RS09585 1949811..1950065 + 255 WP_005545663.1 stability protein StbD Antitoxin
LIN94_RS09590 1950055..1950345 + 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN94_RS09595 1950402..1950740 - 339 WP_005540087.1 cupin domain-containing protein -
LIN94_RS09600 1951081..1951533 + 453 WP_006710245.1 50S ribosomal protein L11 methyltransferase -
LIN94_RS09605 1951704..1953092 + 1389 WP_005567594.1 tRNA 5-hydroxyuridine modification protein YegQ -
LIN94_RS09610 1953389..1954480 + 1092 WP_005545654.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T220473 WP_005540089.1 NZ_CP085092:1950055-1950345 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T220473 NZ_CP117049:185375-185482 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9294.53 Da        Isoelectric Point: 3.9649

>AT220473 WP_005545663.1 NZ_CP085092:1949811-1950065 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT220473 NZ_CP117049:c185327-185261 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure

References