Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1182558..1183227 Replicon chromosome
Accession NZ_CP085092
Organism Aggregatibacter actinomycetemcomitans strain 30R

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LIN94_RS06010 Protein ID WP_084821571.1
Coordinates 1182558..1182896 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LIN94_RS06015 Protein ID WP_014167717.1
Coordinates 1182946..1183227 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN94_RS05985 1177993..1178421 + 429 WP_019518326.1 DUF2726 domain-containing protein -
LIN94_RS05990 1178505..1181369 + 2865 WP_005566593.1 valine--tRNA ligase -
LIN94_RS05995 1181436..1182329 + 894 WP_005545804.1 hypothetical protein -
LIN94_RS06000 1182326..1182448 - 123 WP_005573281.1 hypothetical protein -
LIN94_RS06005 1182448..1182564 - 117 WP_005545808.1 hypothetical protein -
LIN94_RS06010 1182558..1182896 - 339 WP_084821571.1 HipA N-terminal domain-containing protein Toxin
LIN94_RS06015 1182946..1183227 - 282 WP_014167717.1 helix-turn-helix domain-containing protein Antitoxin
LIN94_RS06020 1183371..1184888 - 1518 WP_005545812.1 DHA2 family efflux MFS transporter permease subunit -
LIN94_RS06025 1184898..1186058 - 1161 WP_005545814.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
LIN94_RS06030 1186267..1186749 + 483 WP_005544145.1 Dps family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13118.88 Da        Isoelectric Point: 8.6930

>T220467 WP_084821571.1 NZ_CP085092:c1182896-1182558 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPENEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Download         Length: 339 bp

>T220467 NZ_CP117035:125229-125609 [Salmonella enterica]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10508.00 Da        Isoelectric Point: 4.8356

>AT220467 WP_014167717.1 NZ_CP085092:c1183227-1182946 [Aggregatibacter actinomycetemcomitans]
MVITTAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Download         Length: 282 bp

>AT220467 NZ_CP117035:125008-125229 [Salmonella enterica]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References