Detailed information of TA system TA220467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1182558..1183227
• Replicon: chromosome
• Accession: NZ_CP085092
• Organism: Aggregatibacter actinomycetemcomitans strain 30R

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LIN94_RS06010
• Protein ID: WP_084821571.1
• Coordinates: 1182558..1182896 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LIN94_RS06015
• Protein ID: WP_014167717.1
• Coordinates: 1182946..1183227 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN94_RS05985	1177993..1178421	+	429	WP_019518326.1	DUF2726 domain-containing protein	-
LIN94_RS05990	1178505..1181369	+	2865	WP_005566593.1	valine--tRNA ligase	-
LIN94_RS05995	1181436..1182329	+	894	WP_005545804.1	hypothetical protein	-
LIN94_RS06000	1182326..1182448	-	123	WP_005573281.1	hypothetical protein	-
LIN94_RS06005	1182448..1182564	-	117	WP_005545808.1	hypothetical protein	-
LIN94_RS06010	1182558..1182896	-	339	WP_084821571.1	HipA N-terminal domain-containing protein	Toxin
LIN94_RS06015	1182946..1183227	-	282	WP_014167717.1	helix-turn-helix domain-containing protein	Antitoxin
LIN94_RS06020	1183371..1184888	-	1518	WP_005545812.1	DHA2 family efflux MFS transporter permease subunit	-
LIN94_RS06025	1184898..1186058	-	1161	WP_005545814.1	EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit	-
LIN94_RS06030	1186267..1186749	+	483	WP_005544145.1	Dps family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-88)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13118.88 Da
• Isoelectric Point: 8.6930

>T220467 WP_084821571.1 NZ_CP085092:c1182896-1182558 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPENEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Nucleotide

• Length: 339 bp

>T220467 NZ_CP117035:125229-125609 [Salmonella enterica]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10508.00 Da
• Isoelectric Point: 4.8356

>AT220467 WP_014167717.1 NZ_CP085092:c1183227-1182946 [Aggregatibacter actinomycetemcomitans]
MVITTAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Nucleotide

• Length: 282 bp

>AT220467 NZ_CP117035:125008-125229 [Salmonella enterica]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA