Detailed information of TA system TA220466

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 1145031..1145623
• Replicon: chromosome
• Accession: NZ_CP085092
• Organism: Aggregatibacter actinomycetemcomitans strain 30R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LIN94_RS05830
• Protein ID: WP_014167707.1
• Coordinates: 1145031..1145330 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN94_RS05835
• Protein ID: WP_005568148.1
• Coordinates: 1145327..1145623 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN94_RS05805	1140310..1141524	-	1215	WP_014167705.1	molybdopterin molybdotransferase MoeA	-
LIN94_RS05810	1141653..1142309	+	657	WP_005568155.1	GTP cyclohydrolase I FolE	-
LIN94_RS05815	1142410..1143852	-	1443	WP_005568153.1	serine-type D-Ala-D-Ala carboxypeptidase	-
LIN94_RS05820	1144012..1144488	+	477	WP_005568152.1	transcription elongation factor GreA	-
LIN94_RS05825	1144561..1144863	-	303	WP_005568150.1	ribosome assembly RNA-binding protein YhbY	-
LIN94_RS05830	1145031..1145330	+	300	WP_014167707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN94_RS05835	1145327..1145623	+	297	WP_005568148.1	putative addiction module antidote protein	Antitoxin
LIN94_RS05840	1145656..1146270	-	615	WP_005568146.1	riboflavin synthase	-
LIN94_RS05845	1146297..1147694	+	1398	WP_005568144.1	MATE family efflux transporter	-
LIN94_RS05850	1147998..1148477	-	480	WP_025298305.1	Cys-tRNA(Pro) deacylase	-
LIN94_RS05855	1148538..1149341	+	804	WP_233112656.1	oxidoreductase	-
LIN94_RS05860	1149314..1149775	+	462	Protein_1127	extracellular solute-binding protein	-
LIN94_RS05865	1149750..1150547	+	798	WP_005568139.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-92)

Antitoxin

• Uncharacterized protein HI1420 (5-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11406.53 Da
• Isoelectric Point: 10.6671

>T220466 WP_014167707.1 NZ_CP085092:1145031-1145330 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Nucleotide

• Length: 300 bp

>T220466 NZ_CP117035:112591-113007 [Salmonella enterica]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10939.44 Da
• Isoelectric Point: 4.4155

>AT220466 WP_005568148.1 NZ_CP085092:1145327-1145623 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Nucleotide

• Length: 297 bp

>AT220466 NZ_CP117035:112364-112594 [Salmonella enterica]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA