Detailed information of TA system TA220461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1304349..1304899
• Replicon: chromosome
• Accession: NZ_CP085091
• Organism: Aggregatibacter actinomycetemcomitans strain 30S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: LIN93_RS06670
• Protein ID: WP_005545988.1
• Coordinates: 1304349..1304615 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: LIN93_RS06675
• Protein ID: WP_005539223.1
• Coordinates: 1304627..1304899 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN93_RS06635	1299529..1300437	-	909	WP_025298347.1	hypothetical protein	-
LIN93_RS06640	1300528..1301193	-	666	WP_005567468.1	S24 family peptidase	-
LIN93_RS06645	1301294..1301533	+	240	WP_005567469.1	hypothetical protein	-
LIN93_RS06650	1301560..1301895	+	336	WP_025298348.1	hypothetical protein	-
LIN93_RS06655	1302017..1302433	+	417	WP_025298349.1	hypothetical protein	-
LIN93_RS06660	1302433..1302552	-	120	Protein_1283	Arm DNA-binding domain-containing protein	-
LIN93_RS06665	1302758..1304317	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
LIN93_RS06670	1304349..1304615	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LIN93_RS06675	1304627..1304899	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LIN93_RS06680	1305154..1306506	-	1353	WP_025298350.1	anaerobic C4-dicarboxylate transporter DcuC	-
LIN93_RS06690	1306945..1307400	+	456	WP_005545995.1	ribosome maturation factor RimP	-
LIN93_RS06695	1307424..1308920	+	1497	WP_005567486.1	transcription termination factor NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T220461 WP_005545988.1 NZ_CP085091:c1304615-1304349 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T220461 NZ_CP117033:c4801835-4801524 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT220461 WP_005539223.1 NZ_CP085091:c1304899-1304627 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT220461 NZ_CP117033:c4801523-4801233 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: X2JVL6

Antitoxin

• AlphaFold DB: X2JQ67