220458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1145031..1145623 Replicon chromosome
Accession NZ_CP085091
Organism Aggregatibacter actinomycetemcomitans strain 30S

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LIN93_RS05830 Protein ID WP_014167707.1
Coordinates 1145031..1145330 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LIN93_RS05835 Protein ID WP_005568148.1
Coordinates 1145327..1145623 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN93_RS05805 1140310..1141524 - 1215 WP_014167705.1 molybdopterin molybdotransferase MoeA -
LIN93_RS05810 1141653..1142309 + 657 WP_005568155.1 GTP cyclohydrolase I FolE -
LIN93_RS05815 1142410..1143852 - 1443 WP_005568153.1 serine-type D-Ala-D-Ala carboxypeptidase -
LIN93_RS05820 1144012..1144488 + 477 WP_005568152.1 transcription elongation factor GreA -
LIN93_RS05825 1144561..1144863 - 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
LIN93_RS05830 1145031..1145330 + 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN93_RS05835 1145327..1145623 + 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
LIN93_RS05840 1145656..1146270 - 615 WP_005568146.1 riboflavin synthase -
LIN93_RS05845 1146297..1147694 + 1398 WP_005568144.1 MATE family efflux transporter -
LIN93_RS05850 1147998..1148477 - 480 WP_025298305.1 Cys-tRNA(Pro) deacylase -
LIN93_RS05855 1148538..1149341 + 804 WP_233112656.1 oxidoreductase -
LIN93_RS05860 1149314..1149775 + 462 Protein_1127 extracellular solute-binding protein -
LIN93_RS05865 1149750..1150547 + 798 WP_005568139.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T220458 WP_014167707.1 NZ_CP085091:1145031-1145330 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T220458 NZ_CP117033:c4174541-4174254 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT220458 WP_005568148.1 NZ_CP085091:1145327-1145623 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp

>AT220458 NZ_CP117033:c4174267-4173965 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References