Detailed information of TA system TA220457

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1940018..1940552
• Replicon: chromosome
• Accession: NZ_CP085090
• Organism: Aggregatibacter actinomycetemcomitans strain 31R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FYB7
• Locus tag: LIN96_RS09545
• Protein ID: WP_005540089.1
• Coordinates: 1940262..1940552 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN96_RS09540
• Protein ID: WP_005545663.1
• Coordinates: 1940018..1940272 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN96_RS09510	1935743..1936840	+	1098	WP_005567586.1	histidinol-phosphate transaminase	-
LIN96_RS09515	1936851..1938182	+	1332	WP_249847495.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
LIN96_RS09520	1938270..1938737	-	468	WP_005565412.1	ribonuclease HI	-
LIN96_RS09525	1938805..1939566	+	762	WP_005567590.1	DNA polymerase III subunit epsilon	-
LIN96_RS09540	1940018..1940272	+	255	WP_005545663.1	stability protein StbD	Antitoxin
LIN96_RS09545	1940262..1940552	+	291	WP_005540089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN96_RS09550	1940609..1940947	-	339	WP_005540087.1	cupin domain-containing protein	-
LIN96_RS09555	1941288..1941740	+	453	WP_006710245.1	50S ribosomal protein L11 methyltransferase	-
LIN96_RS09560	1941911..1943299	+	1389	WP_005567594.1	tRNA 5-hydroxyuridine modification protein YegQ	-
LIN96_RS09565	1943596..1944687	+	1092	WP_005545654.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11509.34 Da
• Isoelectric Point: 10.7396

>T220457 WP_005540089.1 NZ_CP085090:1940262-1940552 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T220457 NZ_CP117033:3763310-3763585 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT220457 WP_005545663.1 NZ_CP085090:1940018-1940272 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Nucleotide

• Length: 255 bp

>AT220457 NZ_CP117033:c3763575-3763153 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A142FYB7