Detailed information of TA system TA220455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 1857130..1857632
• Replicon: chromosome
• Accession: NZ_CP085090
• Organism: Aggregatibacter actinomycetemcomitans strain 31R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: LIN96_RS09200
• Protein ID: WP_005547296.1
• Coordinates: 1857130..1857381 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4W640
• Locus tag: LIN96_RS09205
• Protein ID: WP_005556313.1
• Coordinates: 1857378..1857632 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN96_RS09180	1852436..1853629	-	1194	WP_005556328.1	hypothetical protein	-
LIN96_RS09185	1853638..1854414	-	777	WP_005556324.1	glycosyltransferase family 25 protein	-
LIN96_RS09190	1854545..1856068	+	1524	WP_249847480.1	polysaccharide biosynthesis protein	-
LIN96_RS09195	1856065..1857021	+	957	WP_005556319.1	polysaccharide pyruvyl transferase family protein	-
LIN96_RS09200	1857130..1857381	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
LIN96_RS09205	1857378..1857632	+	255	WP_005556313.1	Txe/YoeB family addiction module toxin	Antitoxin
LIN96_RS09210	1857645..1858388	+	744	WP_025298490.1	YdcF family protein	-
LIN96_RS09215	1858565..1859392	+	828	WP_005556311.1	DNA ligase	-
LIN96_RS09220	1859525..1861699	-	2175	WP_005556309.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T220455 WP_005547296.1 NZ_CP085090:1857130-1857381 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T220455 NZ_CP117033:2467114-2467398 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10217.71 Da
• Isoelectric Point: 8.8844

>AT220455 WP_005556313.1 NZ_CP085090:1857378-1857632 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT220455 NZ_CP117033:2466876-2467124 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: S4W640