Detailed information of TA system TA220453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1294447..1294997
• Replicon: chromosome
• Accession: NZ_CP085090
• Organism: Aggregatibacter actinomycetemcomitans strain 31R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: LIN96_RS06605
• Protein ID: WP_005545988.1
• Coordinates: 1294447..1294713 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: LIN96_RS06610
• Protein ID: WP_005539223.1
• Coordinates: 1294725..1294997 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN96_RS06570	1289627..1290535	-	909	WP_025298347.1	hypothetical protein	-
LIN96_RS06575	1290626..1291291	-	666	WP_005567468.1	S24 family peptidase	-
LIN96_RS06580	1291392..1291631	+	240	WP_005567469.1	hypothetical protein	-
LIN96_RS06585	1291658..1291993	+	336	WP_025298348.1	hypothetical protein	-
LIN96_RS06590	1292115..1292531	+	417	WP_025298349.1	hypothetical protein	-
LIN96_RS06595	1292531..1292650	-	120	Protein_1271	Arm DNA-binding domain-containing protein	-
LIN96_RS06600	1292856..1294415	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
LIN96_RS06605	1294447..1294713	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LIN96_RS06610	1294725..1294997	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LIN96_RS06615	1295252..1296604	-	1353	WP_025298350.1	anaerobic C4-dicarboxylate transporter DcuC	-
LIN96_RS06625	1297043..1297498	+	456	WP_005545995.1	ribosome maturation factor RimP	-
LIN96_RS06630	1297522..1299018	+	1497	WP_005567486.1	transcription termination factor NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T220453 WP_005545988.1 NZ_CP085090:c1294713-1294447 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T220453 NZ_CP117033:c1028234-1027707 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT220453 WP_005539223.1 NZ_CP085090:c1294997-1294725 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT220453 NZ_CP117033:c1028521-1028231 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: X2JVL6

Antitoxin

• AlphaFold DB: X2JQ67