Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1172677..1173346 Replicon chromosome
Accession NZ_CP085090
Organism Aggregatibacter actinomycetemcomitans strain 31R

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LIN96_RS05950 Protein ID WP_084821571.1
Coordinates 1172677..1173015 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LIN96_RS05955 Protein ID WP_014167717.1
Coordinates 1173065..1173346 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN96_RS05925 1168112..1168540 + 429 WP_019518326.1 DUF2726 domain-containing protein -
LIN96_RS05930 1168624..1171488 + 2865 WP_005566593.1 valine--tRNA ligase -
LIN96_RS05935 1171555..1172448 + 894 WP_005545804.1 hypothetical protein -
LIN96_RS05940 1172445..1172567 - 123 WP_005573281.1 hypothetical protein -
LIN96_RS05945 1172567..1172683 - 117 WP_005545808.1 hypothetical protein -
LIN96_RS05950 1172677..1173015 - 339 WP_084821571.1 HipA N-terminal domain-containing protein Toxin
LIN96_RS05955 1173065..1173346 - 282 WP_014167717.1 helix-turn-helix domain-containing protein Antitoxin
LIN96_RS05960 1173490..1175007 - 1518 WP_005545812.1 DHA2 family efflux MFS transporter permease subunit -
LIN96_RS05965 1175017..1176177 - 1161 WP_005545814.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
LIN96_RS05970 1176386..1176868 + 483 WP_005544145.1 Dps family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13118.88 Da        Isoelectric Point: 8.6930

>T220451 WP_084821571.1 NZ_CP085090:c1173015-1172677 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPENEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Download         Length: 339 bp

>T220451 NZ_CP117033:870237-870650 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10508.00 Da        Isoelectric Point: 4.8356

>AT220451 WP_014167717.1 NZ_CP085090:c1173346-1173065 [Aggregatibacter actinomycetemcomitans]
MVITTAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Download         Length: 282 bp

>AT220451 NZ_CP117033:869990-870256 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References