Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1135192..1135784 Replicon chromosome
Accession NZ_CP085090
Organism Aggregatibacter actinomycetemcomitans strain 31R

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LIN96_RS05770 Protein ID WP_014167707.1
Coordinates 1135192..1135491 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LIN96_RS05775 Protein ID WP_005568148.1
Coordinates 1135488..1135784 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN96_RS05745 1130471..1131685 - 1215 WP_014167705.1 molybdopterin molybdotransferase MoeA -
LIN96_RS05750 1131814..1132470 + 657 WP_005568155.1 GTP cyclohydrolase I FolE -
LIN96_RS05755 1132571..1134013 - 1443 WP_005568153.1 serine-type D-Ala-D-Ala carboxypeptidase -
LIN96_RS05760 1134173..1134649 + 477 WP_005568152.1 transcription elongation factor GreA -
LIN96_RS05765 1134722..1135024 - 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
LIN96_RS05770 1135192..1135491 + 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN96_RS05775 1135488..1135784 + 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
LIN96_RS05780 1135817..1136431 - 615 WP_005568146.1 riboflavin synthase -
LIN96_RS05785 1136458..1137855 + 1398 WP_005568144.1 MATE family efflux transporter -
LIN96_RS05790 1138159..1138638 - 480 WP_025298305.1 Cys-tRNA(Pro) deacylase -
LIN96_RS05795 1138699..1139502 + 804 WP_233112656.1 oxidoreductase -
LIN96_RS05800 1139475..1139936 + 462 Protein_1116 extracellular solute-binding protein -
LIN96_RS05805 1139911..1140708 + 798 WP_005568139.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T220450 WP_014167707.1 NZ_CP085090:1135192-1135491 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T220450 NZ_CP117033:364861-365136 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT220450 WP_005568148.1 NZ_CP085090:1135488-1135784 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp

>AT220450 NZ_CP117033:364598-364858 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References