Detailed information of TA system TA220449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1782083..1782617
• Replicon: chromosome
• Accession: NZ_CP085089
• Organism: Aggregatibacter actinomycetemcomitans strain 31S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FYB7
• Locus tag: LIN92_RS08740
• Protein ID: WP_005540089.1
• Coordinates: 1782327..1782617 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LIN92_RS08735
• Protein ID: WP_005545663.1
• Coordinates: 1782083..1782337 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN92_RS08705	1777808..1778905	+	1098	WP_005567586.1	histidinol-phosphate transaminase	-
LIN92_RS08710	1778916..1780247	+	1332	WP_249847495.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
LIN92_RS08715	1780335..1780802	-	468	WP_005565412.1	ribonuclease HI	-
LIN92_RS08720	1780870..1781631	+	762	WP_005567590.1	DNA polymerase III subunit epsilon	-
LIN92_RS08735	1782083..1782337	+	255	WP_005545663.1	stability protein StbD	Antitoxin
LIN92_RS08740	1782327..1782617	+	291	WP_005540089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN92_RS08745	1782674..1783012	-	339	WP_005540087.1	cupin domain-containing protein	-
LIN92_RS08750	1783353..1783805	+	453	WP_006710245.1	50S ribosomal protein L11 methyltransferase	-
LIN92_RS08755	1783976..1785364	+	1389	WP_005567594.1	tRNA 5-hydroxyuridine modification protein YegQ	-
LIN92_RS08760	1785661..1786752	+	1092	WP_005545654.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11509.34 Da
• Isoelectric Point: 10.7396

>T220449 WP_005540089.1 NZ_CP085089:1782327-1782617 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T220449 NZ_CP117033:316725-317093 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT220449 WP_005545663.1 NZ_CP085089:1782083-1782337 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Nucleotide

• Length: 255 bp

>AT220449 NZ_CP117033:316507-316728 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A142FYB7