Detailed information of TA system TA220447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 1699195..1699697
• Replicon: chromosome
• Accession: NZ_CP085089
• Organism: Aggregatibacter actinomycetemcomitans strain 31S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: LIN92_RS08395
• Protein ID: WP_005547296.1
• Coordinates: 1699195..1699446 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4W640
• Locus tag: LIN92_RS08400
• Protein ID: WP_005556313.1
• Coordinates: 1699443..1699697 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN92_RS08375	1694501..1695694	-	1194	WP_005556328.1	hypothetical protein	-
LIN92_RS08380	1695703..1696479	-	777	WP_005556324.1	glycosyltransferase family 25 protein	-
LIN92_RS08385	1696610..1698133	+	1524	WP_249847480.1	polysaccharide biosynthesis protein	-
LIN92_RS08390	1698130..1699086	+	957	WP_005556319.1	polysaccharide pyruvyl transferase family protein	-
LIN92_RS08395	1699195..1699446	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
LIN92_RS08400	1699443..1699697	+	255	WP_005556313.1	Txe/YoeB family addiction module toxin	Antitoxin
LIN92_RS08405	1699710..1700453	+	744	WP_025298490.1	YdcF family protein	-
LIN92_RS08410	1700630..1701457	+	828	WP_005556311.1	DNA ligase	-
LIN92_RS08415	1701590..1703764	-	2175	WP_005556309.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T220447 WP_005547296.1 NZ_CP085089:1699195-1699446 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T220447 NZ_CP117029:c2145112-2144690 [Vibrio tubiashii]
TTGAGTAAGAAAATCAACTACATGCTCGATACGTGTATTTGTTCGTTCATTATGAGAGAGCAACCAATTACAGTGCTTAA
AAAACTTCAAGCCGTGGTCGGTAAGCAACATCGAATCGTTATTTCAGCAATTACCTATCAAGAAATGCAGTATGGACTAC
TGGGGAAAAAAGCCTCACAGAAACATAAAGTGCTTGTTGAAGCCTTTCTCAAGCGAGTTGATGAGATTTTACCATGGGAC
AAAGCGGCTGTTGATGCAACGACGGAAGTTAAGCGCGACTTAATGGCTAAGGGGACACCGATTGGTAGCAACGATACCGC
TATTGCAGGTCATGCCATTGCAGCAGGTTGTGTGCTTGTCACGAACAACACTAGAGAGTTTCAGCGCGTAGAAGGTTTAA
AGCTTGAAGATTGGGTTCACTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10217.71 Da
• Isoelectric Point: 8.8844

>AT220447 WP_005556313.1 NZ_CP085089:1699443-1699697 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT220447 NZ_CP117029:c2145338-2145105 [Vibrio tubiashii]
ATGAGAACAGTATCAATTTTTAAAAATGGCAAGAATCAAGCGGTGCGCTTGCCAAAGGATTTTGAGTTTGATGGAGTGAA
TGAGCTCGAAATTCACAAAGAGGGGGACGTCATCACTTTACGTCCTGCTCGCCCGGATTGGCTTTCTTTTGGTGAGCAAG
AAAAGGCTGATGATGATTTCATGGTTAACCGTGAAGATGTAATGACAGACGAAGGGCGATTCGATTTTGAGTAA

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: S4W640