Detailed information of TA system TA220445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1136690..1137240
• Replicon: chromosome
• Accession: NZ_CP085089
• Organism: Aggregatibacter actinomycetemcomitans strain 31S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: LIN92_RS05805
• Protein ID: WP_005545988.1
• Coordinates: 1136690..1136956 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: LIN92_RS05810
• Protein ID: WP_005539223.1
• Coordinates: 1136968..1137240 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN92_RS05770	1131870..1132778	-	909	WP_025298347.1	hypothetical protein	-
LIN92_RS05775	1132869..1133534	-	666	WP_005567468.1	S24 family peptidase	-
LIN92_RS05780	1133635..1133874	+	240	WP_005567469.1	hypothetical protein	-
LIN92_RS05785	1133901..1134236	+	336	WP_025298348.1	hypothetical protein	-
LIN92_RS05790	1134358..1134774	+	417	WP_025298349.1	hypothetical protein	-
LIN92_RS05795	1134774..1134893	-	120	Protein_1111	Arm DNA-binding domain-containing protein	-
LIN92_RS05800	1135099..1136658	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
LIN92_RS05805	1136690..1136956	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LIN92_RS05810	1136968..1137240	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LIN92_RS05815	1137495..1138847	-	1353	WP_025298350.1	anaerobic C4-dicarboxylate transporter DcuC	-
LIN92_RS05825	1139286..1139741	+	456	WP_005545995.1	ribosome maturation factor RimP	-
LIN92_RS05830	1139765..1141261	+	1497	WP_005567486.1	transcription termination factor NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T220445 WP_005545988.1 NZ_CP085089:c1136956-1136690 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T220445 NZ_CP117029:c1637441-1637172 [Vibrio tubiashii]
ATGAGTAGCAGTCTACGTTTACTATCGTGGACTGACGACGCTTGGGGTGACTACCTGTATTGGCAAACGCAAGACAAAAA
AACGCTCAAGCGCATCAACAAACTCATCAATGATGTTAAGCGTTCTCCTTTTGAGGGCATTGGTAAACCTGAACCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACCAACAGGCTTGTTTATGCAGTCGATGATCAAGCGATA
ACCATTATTTCGTGTCGTTACCACTACTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT220445 WP_005539223.1 NZ_CP085089:c1137240-1136968 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT220445 NZ_CP117029:c1637688-1637434 [Vibrio tubiashii]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTTAAAGCTGTTCTAGACGGTGTAGTTAATGACGCAGATACAAC
AGTCATTACACGCCGTGACTCTGAAGATGCTGTGGTTATGTCTTTAGATTACTACAATAGCTTAATGGAAACAGTGCATT
TACTACGCTCTCCTCAGAATGCTGAACACCTAAACCGCTCCATAGCACAGTATCGTGCTGGTCAAACAACTGAGCGAGAT
TTAATTGATGAGTAG

Structures

Toxin

• AlphaFold DB: X2JVL6

Antitoxin

• AlphaFold DB: X2JQ67