Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 977435..978027 Replicon chromosome
Accession NZ_CP085089
Organism Aggregatibacter actinomycetemcomitans strain 31S

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LIN92_RS04965 Protein ID WP_014167707.1
Coordinates 977435..977734 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LIN92_RS04970 Protein ID WP_005568148.1
Coordinates 977731..978027 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN92_RS04940 972714..973928 - 1215 WP_014167705.1 molybdopterin molybdotransferase MoeA -
LIN92_RS04945 974057..974713 + 657 WP_005568155.1 GTP cyclohydrolase I FolE -
LIN92_RS04950 974814..976256 - 1443 WP_005568153.1 serine-type D-Ala-D-Ala carboxypeptidase -
LIN92_RS04955 976416..976892 + 477 WP_005568152.1 transcription elongation factor GreA -
LIN92_RS04960 976965..977267 - 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
LIN92_RS04965 977435..977734 + 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN92_RS04970 977731..978027 + 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
LIN92_RS04975 978060..978674 - 615 WP_005568146.1 riboflavin synthase -
LIN92_RS04980 978701..980098 + 1398 WP_005568144.1 MATE family efflux transporter -
LIN92_RS04985 980402..980881 - 480 WP_025298305.1 Cys-tRNA(Pro) deacylase -
LIN92_RS04990 980942..981745 + 804 WP_233112656.1 oxidoreductase -
LIN92_RS04995 981718..982179 + 462 Protein_955 extracellular solute-binding protein -
LIN92_RS05000 982154..982951 + 798 WP_005568139.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T220442 WP_014167707.1 NZ_CP085089:977435-977734 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T220442 NZ_CP117024:189107-189391 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACAAAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAAAACACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGTGCAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT220442 WP_005568148.1 NZ_CP085089:977731-978027 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp

>AT220442 NZ_CP117024:188734-189126 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAACTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGGTGAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATAATAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References