Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1314876..1315359 | Replicon | chromosome |
Accession | NZ_CP085088 | ||
Organism | Streptococcus suis strain Ssuis_MA1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D5AIX4 |
Locus tag | LIO33_RS06475 | Protein ID | WP_012027435.1 |
Coordinates | 1314876..1315136 (-) | Length | 87 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0Z8BIX7 |
Locus tag | LIO33_RS06480 | Protein ID | WP_012775256.1 |
Coordinates | 1315138..1315359 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LIO33_RS06450 | 1310261..1311490 | - | 1230 | WP_012775253.1 | tetratricopeptide repeat protein | - |
LIO33_RS06455 | 1311480..1312646 | - | 1167 | WP_012775254.1 | AI-2E family transporter | - |
LIO33_RS06460 | 1312782..1313786 | + | 1005 | WP_012028380.1 | lactonase family protein | - |
LIO33_RS06465 | 1313850..1314035 | + | 186 | WP_002935693.1 | hypothetical protein | - |
LIO33_RS06470 | 1314068..1314709 | - | 642 | WP_012775255.1 | HAD family hydrolase | - |
LIO33_RS06475 | 1314876..1315136 | - | 261 | WP_012027435.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LIO33_RS06480 | 1315138..1315359 | - | 222 | WP_012775256.1 | DUF6290 family protein | Antitoxin |
LIO33_RS06485 | 1315669..1316976 | - | 1308 | WP_002935704.1 | phosphopyruvate hydratase | - |
LIO33_RS06490 | 1317126..1317578 | + | 453 | WP_012028381.1 | DUF1694 domain-containing protein | - |
LIO33_RS06495 | 1317644..1317814 | - | 171 | WP_014636067.1 | hypothetical protein | - |
LIO33_RS06500 | 1317805..1318932 | - | 1128 | WP_012028382.1 | glycerate kinase | - |
LIO33_RS06505 | 1319040..1319690 | + | 651 | WP_012027441.1 | HAD family hydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 1320127..1320714 | 587 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10273.79 Da Isoelectric Point: 9.3944
>T220439 WP_012027435.1 NZ_CP085088:c1315136-1314876 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY
Download Length: 261 bp
>T220439 NZ_CP117020:c4396130-4395912 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8566.55 Da Isoelectric Point: 4.4791
>AT220439 WP_012775256.1 NZ_CP085088:c1315359-1315138 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL
Download Length: 222 bp
>AT220439 NZ_CP117020:c4396530-4396156 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2K1T1M7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8BIX7 |