Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1314876..1315359 Replicon chromosome
Accession NZ_CP085088
Organism Streptococcus suis strain Ssuis_MA1

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag LIO33_RS06475 Protein ID WP_012027435.1
Coordinates 1314876..1315136 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag LIO33_RS06480 Protein ID WP_012775256.1
Coordinates 1315138..1315359 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO33_RS06450 1310261..1311490 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
LIO33_RS06455 1311480..1312646 - 1167 WP_012775254.1 AI-2E family transporter -
LIO33_RS06460 1312782..1313786 + 1005 WP_012028380.1 lactonase family protein -
LIO33_RS06465 1313850..1314035 + 186 WP_002935693.1 hypothetical protein -
LIO33_RS06470 1314068..1314709 - 642 WP_012775255.1 HAD family hydrolase -
LIO33_RS06475 1314876..1315136 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO33_RS06480 1315138..1315359 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
LIO33_RS06485 1315669..1316976 - 1308 WP_002935704.1 phosphopyruvate hydratase -
LIO33_RS06490 1317126..1317578 + 453 WP_012028381.1 DUF1694 domain-containing protein -
LIO33_RS06495 1317644..1317814 - 171 WP_014636067.1 hypothetical protein -
LIO33_RS06500 1317805..1318932 - 1128 WP_012028382.1 glycerate kinase -
LIO33_RS06505 1319040..1319690 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1320127..1320714 587


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T220439 WP_012027435.1 NZ_CP085088:c1315136-1314876 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T220439 NZ_CP117020:c4396130-4395912 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT220439 WP_012775256.1 NZ_CP085088:c1315359-1315138 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT220439 NZ_CP117020:c4396530-4396156 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References