Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 581419..581905 Replicon chromosome
Accession NZ_CP085088
Organism Streptococcus suis strain Ssuis_MA1

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag LIO33_RS02940 Protein ID WP_011922754.1
Coordinates 581636..581905 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag LIO33_RS02935 Protein ID WP_002938604.1
Coordinates 581419..581646 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO33_RS02910 576462..576911 - 450 WP_009909619.1 MarR family transcriptional regulator -
LIO33_RS02915 577205..578052 + 848 WP_087892711.1 IS630 family transposase -
LIO33_RS02920 578111..578608 + 498 WP_011922751.1 DUF5590 domain-containing protein -
LIO33_RS02925 578605..579786 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
LIO33_RS02930 579801..581147 + 1347 WP_011922752.1 asparagine--tRNA ligase -
LIO33_RS02935 581419..581646 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
LIO33_RS02940 581636..581905 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO33_RS02945 582311..583630 + 1320 WP_012775027.1 MATE family efflux transporter -
LIO33_RS02950 583681..584058 + 378 WP_002937263.1 RidA family protein -
LIO33_RS02955 584080..584967 + 888 WP_011922160.1 RNase adapter RapZ -
LIO33_RS02960 584964..585938 + 975 WP_002937257.1 YvcK family protein -
LIO33_RS02965 585935..586852 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T220437 WP_011922754.1 NZ_CP085088:581636-581905 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T220437 NZ_CP117020:4176256-4176654 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT220437 WP_002938604.1 NZ_CP085088:581419-581646 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT220437 NZ_CP117020:4175960-4176253 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References