Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1939883..1940489 Replicon chromosome
Accession NZ_CP085087
Organism Streptococcus suis strain Ssuis_MA2

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag LIO32_RS09615 Protein ID WP_012775364.1
Coordinates 1939883..1940212 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag LIO32_RS09620 Protein ID WP_012028535.1
Coordinates 1940202..1940489 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO32_RS09585 1935299..1937029 - 1731 WP_023371683.1 membrane protein -
LIO32_RS09590 1937392..1938264 - 873 WP_014736465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LIO32_RS09595 1938283..1938810 - 528 Protein_1852 DUF1697 domain-containing protein -
LIO32_RS09600 1938826..1939083 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin -
LIO32_RS09605 1939085..1939345 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LIO32_RS09610 1939421..1939876 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
LIO32_RS09615 1939883..1940212 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO32_RS09620 1940202..1940489 - 288 WP_012028535.1 hypothetical protein Antitoxin
LIO32_RS09625 1940587..1940955 - 369 WP_023371689.1 hypothetical protein -
LIO32_RS09630 1940948..1941517 - 570 WP_012775700.1 ribonuclease M5 -
LIO32_RS09635 1941501..1942283 - 783 WP_012028536.1 TatD family hydrolase -
LIO32_RS09640 1942390..1942527 - 138 WP_002939016.1 50S ribosomal protein L34 -
LIO32_RS09645 1942695..1943690 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
LIO32_RS09650 1943710..1944522 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
LIO32_RS09655 1944506..1944865 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T220436 WP_012775364.1 NZ_CP085087:c1940212-1939883 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T220436 NZ_CP117020:3834131-3834418 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT220436 WP_012028535.1 NZ_CP085087:c1940489-1940202 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT220436 NZ_CP117020:3834405-3834707 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References