Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1052133..1052634 Replicon chromosome
Accession NZ_CP085087
Organism Streptococcus suis strain Ssuis_MA2

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag LIO32_RS05300 Protein ID WP_024405694.1
Coordinates 1052133..1052399 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag LIO32_RS05305 Protein ID WP_012775104.1
Coordinates 1052383..1052634 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO32_RS05275 1047362..1047598 + 237 WP_226319150.1 hypothetical protein -
LIO32_RS05280 1047765..1048835 + 1071 WP_024405698.1 tyrosine recombinase XerS -
LIO32_RS05285 1048905..1050413 - 1509 WP_024405697.1 phosphoglucomutase -
LIO32_RS05290 1050488..1051429 - 942 WP_024405696.1 sensor histidine kinase -
LIO32_RS05295 1051426..1052091 - 666 WP_024405695.1 response regulator transcription factor -
LIO32_RS05300 1052133..1052399 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO32_RS05305 1052383..1052634 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
LIO32_RS05310 1052726..1054696 - 1971 WP_074389880.1 FtsX-like permease family protein -
LIO32_RS05315 1054697..1055449 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
LIO32_RS05320 1055470..1055847 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
LIO32_RS05325 1055860..1056000 - 141 WP_012775106.1 hypothetical protein -
LIO32_RS05330 1056140..1057306 - 1167 WP_011922414.1 carbamoyl phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T220434 WP_024405694.1 NZ_CP085087:c1052399-1052133 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T220434 NZ_CP117020:3570653-3570826 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT220434 WP_012775104.1 NZ_CP085087:c1052634-1052383 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT220434 NZ_CP117020:3570329-3570625 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References