Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 804634..805120 Replicon chromosome
Accession NZ_CP085087
Organism Streptococcus suis strain Ssuis_MA2

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag LIO32_RS04125 Protein ID WP_011922754.1
Coordinates 804851..805120 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag LIO32_RS04120 Protein ID WP_002938604.1
Coordinates 804634..804861 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO32_RS04095 799967..800512 - 546 WP_002941732.1 NADPH-dependent FMN reductase -
LIO32_RS04100 800575..801024 - 450 WP_024383028.1 MarR family transcriptional regulator -
LIO32_RS04105 801326..801823 + 498 WP_024405519.1 DUF5590 domain-containing protein -
LIO32_RS04110 801820..803001 + 1182 WP_024383693.1 pyridoxal phosphate-dependent aminotransferase -
LIO32_RS04115 803016..804362 + 1347 WP_024405517.1 asparagine--tRNA ligase -
LIO32_RS04120 804634..804861 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
LIO32_RS04125 804851..805120 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO32_RS04130 805526..806850 + 1325 Protein_780 MATE family efflux transporter -
LIO32_RS04135 807034..807411 + 378 WP_002937263.1 RidA family protein -
LIO32_RS04140 807433..808320 + 888 WP_002937261.1 RNase adapter RapZ -
LIO32_RS04145 808317..809291 + 975 WP_024383695.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T220433 WP_011922754.1 NZ_CP085087:804851-805120 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T220433 NZ_CP117020:3276320-3276631 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT220433 WP_002938604.1 NZ_CP085087:804634-804861 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT220433 NZ_CP117020:3276632-3276922 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References