Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 795365..796617 Replicon chromosome
Accession NZ_CP085087
Organism Streptococcus suis strain Ssuis_MA2

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag LIO32_RS04070 Protein ID WP_024405541.1
Coordinates 795841..796617 (+) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag LIO32_RS04065 Protein ID WP_024405542.1
Coordinates 795365..795841 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO32_RS04045 794011..794442 + 432 Protein_763 peptidylprolyl isomerase -
LIO32_RS04050 794481..794885 + 405 Protein_764 DNA primase -
LIO32_RS04055 794887..794955 + 69 Protein_765 DUF5945 family protein -
LIO32_RS04060 795005..795295 + 291 WP_024405543.1 hypothetical protein -
LIO32_RS04065 795365..795841 + 477 WP_024405542.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
LIO32_RS04070 795841..796617 + 777 WP_024405541.1 type II toxin-antitoxin system toxin PezT Toxin
LIO32_RS04075 796614..797513 + 900 WP_216092534.1 AAA family ATPase -
LIO32_RS04080 797617..797805 + 189 Protein_770 nuclear transport factor 2 family protein -
LIO32_RS04085 797818..798468 + 651 WP_216092535.1 SAP domain-containing protein -
LIO32_RS04090 798758..799870 + 1113 WP_172046046.1 UDP-galactopyranose mutase -
LIO32_RS04095 799967..800512 - 546 WP_002941732.1 NADPH-dependent FMN reductase -
LIO32_RS04100 800575..801024 - 450 WP_024383028.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 743905..797101 53196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29222.90 Da        Isoelectric Point: 5.6995

>T220432 WP_024405541.1 NZ_CP085087:795841-796617 [Streptococcus suis]
MRLEEFSEEEFQKALQRTIRAQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Download         Length: 777 bp

>T220432 NZ_CP117020:c2853998-2853891 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.70 Da        Isoelectric Point: 4.3241

>AT220432 WP_024405542.1 NZ_CP085087:795365-795841 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHWVVA

Download         Length: 477 bp

>AT220432 NZ_CP117020:2854056-2854110 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References