Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 565756..566239 Replicon chromosome
Accession NZ_CP085087
Organism Streptococcus suis strain Ssuis_MA2

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag LIO32_RS02955 Protein ID WP_012027435.1
Coordinates 565979..566239 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag LIO32_RS02950 Protein ID WP_012775256.1
Coordinates 565756..565977 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO32_RS02905 561065..561247 + 183 WP_024405996.1 hypothetical protein -
LIO32_RS02910 561339..561950 + 612 WP_024405995.1 hypothetical protein -
LIO32_RS02915 561997..562425 + 429 WP_074389766.1 replication protein -
LIO32_RS02920 562433..562744 + 312 WP_074389767.1 hypothetical protein -
LIO32_RS02925 562762..563175 + 414 WP_024405993.1 hypothetical protein -
LIO32_RS02935 563915..564097 + 183 WP_015647112.1 type II toxin-antitoxin system HicA family toxin -
LIO32_RS02940 564137..564589 + 453 WP_074389768.1 type II toxin-antitoxin system HicB family antitoxin -
LIO32_RS02945 564703..564912 + 210 WP_015647110.1 hypothetical protein -
LIO32_RS02950 565756..565977 + 222 WP_012775256.1 DUF6290 family protein Antitoxin
LIO32_RS02955 565979..566239 + 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO32_RS02960 566406..567047 + 642 WP_023370899.1 HAD family hydrolase -
LIO32_RS02965 567080..567265 - 186 WP_002935693.1 hypothetical protein -
LIO32_RS02970 567329..568333 - 1005 WP_023370897.1 lactonase family protein -
LIO32_RS02975 568469..569635 + 1167 WP_012775254.1 AI-2E family transporter -
LIO32_RS02980 569625..570854 + 1230 WP_023370895.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 555406..570854 15448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T220430 WP_012027435.1 NZ_CP085087:565979-566239 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T220430 NZ_CP117020:c2853031-2852924 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT220430 WP_012775256.1 NZ_CP085087:565756-565977 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT220430 NZ_CP117020:2853079-2853145 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References