Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2243736..2244310 Replicon chromosome
Accession NC_009436
Organism Enterobacter sp. 638

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ENT638_RS10690 Protein ID WP_012017458.1
Coordinates 2243984..2244310 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ENT638_RS10685 Protein ID WP_012017457.1
Coordinates 2243736..2243984 (+) Length 83 a.a.

Genomic Context

ENT638_RS10670ENT638_RS10675ENT638_RS10680ENT638_RS10685ENT638_RS10690ENT638_RS10695ENT638_RS10700ENT638_RS10705ENT638_RS10710
Location: 2240724..2242268 (1545 bp)
Type: Others
Protein ID: WP_012017454.1
Location: 2242268..2242963 (696 bp)
Type: Others
Protein ID: WP_012017455.1
Location: 2242960..2243640 (681 bp)
Type: Others
Protein ID: WP_012017456.1
Location: 2243736..2243984 (249 bp)
Type: Antitoxin
Protein ID: WP_012017457.1
Location: 2243984..2244310 (327 bp)
Type: Toxin
Protein ID: WP_012017458.1
Location: 2244340..2245185 (846 bp)
Type: Others
Protein ID: WP_041689411.1
Location: 2245258..2246913 (1656 bp)
Type: Others
Protein ID: WP_012017460.1
Location: 2246953..2247921 (969 bp)
Type: Others
Protein ID: WP_012017461.1
Location: 2247918..2248610 (693 bp)
Type: Others
Protein ID: WP_012017462.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ENT638_RS106702240724..2242268+1545WP_012017454.1nitrate reductase subunit beta-
ENT638_RS106752242268..2242963+696WP_012017455.1nitrate reductase molybdenum cofactor assembly chaperone-
ENT638_RS106802242960..2243640+681WP_012017456.1respiratory nitrate reductase subunit gamma-
ENT638_RS106852243736..2243984+249WP_012017457.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ENT638_RS106902243984..2244310+327WP_012017458.1endoribonuclease MazFToxin
ENT638_RS106952244340..2245185-846WP_041689411.1N-hydroxyarylamine O-acetyltransferase-
ENT638_RS107002245258..2246913-1656WP_012017460.1iron ABC transporter permease-
ENT638_RS107052246953..2247921-969WP_012017461.1ABC transporter substrate-binding protein-
ENT638_RS107102247918..2248610-693WP_012017462.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-104)

Antitoxin

Antitoxin PemI-like

(4-81)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11767.54 Da        Isoelectric Point: 8.5012

>T22043 WP_012017458.1 NC_009436:2243984-2244310 [Enterobacter sp. 638]
MDYVPEAGDIVWLDFDPQSGHEQAGHRPALVISPASYNGRTSLMLCCPLTSQIKGYPFEVAINAAQRSVALADQIKSLDW
QARKAVKKGKATADELNAVRMRAKVLLG

Download         Length: 327 bp

>T22043 NC_009436:2243984-2244310 [Enterobacter sp. 638]
ATGGACTACGTTCCAGAGGCGGGTGATATCGTCTGGCTTGATTTTGACCCGCAGTCAGGCCACGAACAGGCGGGACATCG
ACCGGCATTGGTCATTTCACCGGCGAGCTATAACGGTCGCACCAGCTTAATGCTTTGCTGCCCGCTGACATCACAGATTA
AGGGATATCCTTTTGAAGTCGCTATTAACGCAGCACAGCGCAGCGTTGCCCTTGCCGACCAGATAAAGAGTCTGGACTGG
CAAGCACGAAAAGCAGTGAAAAAGGGAAAGGCAACGGCTGATGAACTCAATGCGGTGAGAATGCGGGCAAAGGTACTTCT
CGGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9145.28 Da        Isoelectric Point: 4.2334

>AT22043 WP_012017457.1 NC_009436:2243736-2243984 [Enterobacter sp. 638]
MPQVTVKKWGNSPSVRLPVAVMREAELNVDDVVNINVDEEGRIILSPVRNDEPSLESLLSAITDENLHHEITFGEPQGKE
QL

Download         Length: 249 bp

>AT22043 NC_009436:2243736-2243984 [Enterobacter sp. 638]
ATGCCACAAGTCACCGTAAAAAAATGGGGAAACAGCCCTTCCGTCAGGCTTCCTGTCGCGGTTATGCGTGAAGCCGAACT
GAACGTTGATGATGTGGTGAATATCAACGTAGACGAAGAAGGACGCATCATTTTGTCACCCGTCAGAAACGACGAACCGT
CGCTCGAATCGCTGTTATCGGCGATAACGGATGAAAATCTGCACCACGAAATCACTTTTGGTGAACCACAAGGTAAGGAG
CAGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References