Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2243736..2244310 Replicon chromosome
Accession NC_009436
Organism Enterobacter sp. 638

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ENT638_RS10690 Protein ID WP_012017458.1
Coordinates 2243984..2244310 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ENT638_RS10685 Protein ID WP_012017457.1
Coordinates 2243736..2243984 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENT638_RS10670 2240724..2242268 + 1545 WP_012017454.1 nitrate reductase subunit beta -
ENT638_RS10675 2242268..2242963 + 696 WP_012017455.1 nitrate reductase molybdenum cofactor assembly chaperone -
ENT638_RS10680 2242960..2243640 + 681 WP_012017456.1 respiratory nitrate reductase subunit gamma -
ENT638_RS10685 2243736..2243984 + 249 WP_012017457.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ENT638_RS10690 2243984..2244310 + 327 WP_012017458.1 endoribonuclease MazF Toxin
ENT638_RS10695 2244340..2245185 - 846 WP_041689411.1 N-hydroxyarylamine O-acetyltransferase -
ENT638_RS10700 2245258..2246913 - 1656 WP_012017460.1 iron ABC transporter permease -
ENT638_RS10705 2246953..2247921 - 969 WP_012017461.1 ABC transporter substrate-binding protein -
ENT638_RS10710 2247918..2248610 - 693 WP_012017462.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-104)

Antitoxin

Antitoxin PemI-like

(4-81)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11767.54 Da        Isoelectric Point: 8.5012

>T22043 WP_012017458.1 NC_009436:2243984-2244310 [Enterobacter sp. 638]
MDYVPEAGDIVWLDFDPQSGHEQAGHRPALVISPASYNGRTSLMLCCPLTSQIKGYPFEVAINAAQRSVALADQIKSLDW
QARKAVKKGKATADELNAVRMRAKVLLG

Download         Length: 327 bp

>T22043 NC_009436:2243984-2244310 [Enterobacter sp. 638]
ATGGACTACGTTCCAGAGGCGGGTGATATCGTCTGGCTTGATTTTGACCCGCAGTCAGGCCACGAACAGGCGGGACATCG
ACCGGCATTGGTCATTTCACCGGCGAGCTATAACGGTCGCACCAGCTTAATGCTTTGCTGCCCGCTGACATCACAGATTA
AGGGATATCCTTTTGAAGTCGCTATTAACGCAGCACAGCGCAGCGTTGCCCTTGCCGACCAGATAAAGAGTCTGGACTGG
CAAGCACGAAAAGCAGTGAAAAAGGGAAAGGCAACGGCTGATGAACTCAATGCGGTGAGAATGCGGGCAAAGGTACTTCT
CGGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9145.28 Da        Isoelectric Point: 4.2334

>AT22043 WP_012017457.1 NC_009436:2243736-2243984 [Enterobacter sp. 638]
MPQVTVKKWGNSPSVRLPVAVMREAELNVDDVVNINVDEEGRIILSPVRNDEPSLESLLSAITDENLHHEITFGEPQGKE
QL

Download         Length: 249 bp

>AT22043 NC_009436:2243736-2243984 [Enterobacter sp. 638]
ATGCCACAAGTCACCGTAAAAAAATGGGGAAACAGCCCTTCCGTCAGGCTTCCTGTCGCGGTTATGCGTGAAGCCGAACT
GAACGTTGATGATGTGGTGAATATCAACGTAGACGAAGAAGGACGCATCATTTTGTCACCCGTCAGAAACGACGAACCGT
CGCTCGAATCGCTGTTATCGGCGATAACGGATGAAAATCTGCACCACGAAATCACTTTTGGTGAACCACAAGGTAAGGAG
CAGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References